Genome-Wide Mapping of Loci Explaining Variance in Scrotal Circumference in Nellore Cattle

The reproductive performance of bulls has a high impact on the beef cattle industry. Scrotal circumference (SC) is the most recorded reproductive trait in beef herds, and is used as a major selection criterion to improve precocity and fertility. The characterization of genomic regions affecting SC c...

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Main Authors:	Utsunomiya, Yuri T., Carmo, Adriana S., Neves, Haroldo H. R., Carvalheiro, Roberto, Matos, Márcia C., Zavarez, Ludmilla B., Ito, Pier K. R. K., Pérez O'Brien, Ana M., Sölkner, Johann, Porto-Neto, Laercio R., Schenkel, Flávio S., McEwan, John, Cole, John B., da Silva, Marcos V. G. B., Van Tassell, Curtis P., Sonstegard, Tad S., Garcia, José Fernando
Format:	Online
Language:	English
Published:	Public Library of Science 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928245/

id	pubmed-3928245
recordtype	oai_dc
spelling	pubmed-39282452014-02-20 Genome-Wide Mapping of Loci Explaining Variance in Scrotal Circumference in Nellore Cattle Utsunomiya, Yuri T. Carmo, Adriana S. Neves, Haroldo H. R. Carvalheiro, Roberto Matos, Márcia C. Zavarez, Ludmilla B. Ito, Pier K. R. K. Pérez O'Brien, Ana M. Sölkner, Johann Porto-Neto, Laercio R. Schenkel, Flávio S. McEwan, John Cole, John B. da Silva, Marcos V. G. B. Van Tassell, Curtis P. Sonstegard, Tad S. Garcia, José Fernando Research Article The reproductive performance of bulls has a high impact on the beef cattle industry. Scrotal circumference (SC) is the most recorded reproductive trait in beef herds, and is used as a major selection criterion to improve precocity and fertility. The characterization of genomic regions affecting SC can contribute to the identification of diagnostic markers for reproductive performance and uncover molecular mechanisms underlying complex aspects of bovine reproductive biology. In this paper, we report a genome-wide scan for chromosome segments explaining differences in SC, using data of 861 Nellore bulls (Bos indicus) genotyped for over 777,000 single nucleotide polymorphisms. Loci that excel from the genome background were identified on chromosomes 4, 6, 7, 10, 14, 18 and 21. The majority of these regions were previously found to be associated with reproductive and body size traits in cattle. The signal on chromosome 14 replicates the pleiotropic quantitative trait locus encompassing PLAG1 that affects male fertility in cattle and stature in several species. Based on intensive literature mining, SP4, MAGEL2, SH3RF2, PDE5A and SNAI2 are proposed as novel candidate genes for SC, as they affect growth and testicular size in other animal models. These findings contribute to linking reproductive phenotypes to gene functions, and may offer new insights on the molecular biology of male fertility. Public Library of Science 2014-02-18 /pmc/articles/PMC3928245/ /pubmed/24558400 http://dx.doi.org/10.1371/journal.pone.0088561 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Utsunomiya, Yuri T. Carmo, Adriana S. Neves, Haroldo H. R. Carvalheiro, Roberto Matos, Márcia C. Zavarez, Ludmilla B. Ito, Pier K. R. K. Pérez O'Brien, Ana M. Sölkner, Johann Porto-Neto, Laercio R. Schenkel, Flávio S. McEwan, John Cole, John B. da Silva, Marcos V. G. B. Van Tassell, Curtis P. Sonstegard, Tad S. Garcia, José Fernando
spellingShingle	Utsunomiya, Yuri T. Carmo, Adriana S. Neves, Haroldo H. R. Carvalheiro, Roberto Matos, Márcia C. Zavarez, Ludmilla B. Ito, Pier K. R. K. Pérez O'Brien, Ana M. Sölkner, Johann Porto-Neto, Laercio R. Schenkel, Flávio S. McEwan, John Cole, John B. da Silva, Marcos V. G. B. Van Tassell, Curtis P. Sonstegard, Tad S. Garcia, José Fernando Genome-Wide Mapping of Loci Explaining Variance in Scrotal Circumference in Nellore Cattle
author_facet	Utsunomiya, Yuri T. Carmo, Adriana S. Neves, Haroldo H. R. Carvalheiro, Roberto Matos, Márcia C. Zavarez, Ludmilla B. Ito, Pier K. R. K. Pérez O'Brien, Ana M. Sölkner, Johann Porto-Neto, Laercio R. Schenkel, Flávio S. McEwan, John Cole, John B. da Silva, Marcos V. G. B. Van Tassell, Curtis P. Sonstegard, Tad S. Garcia, José Fernando
author_sort	Utsunomiya, Yuri T.
title	Genome-Wide Mapping of Loci Explaining Variance in Scrotal Circumference in Nellore Cattle
title_short	Genome-Wide Mapping of Loci Explaining Variance in Scrotal Circumference in Nellore Cattle
title_full	Genome-Wide Mapping of Loci Explaining Variance in Scrotal Circumference in Nellore Cattle
title_fullStr	Genome-Wide Mapping of Loci Explaining Variance in Scrotal Circumference in Nellore Cattle
title_full_unstemmed	Genome-Wide Mapping of Loci Explaining Variance in Scrotal Circumference in Nellore Cattle
title_sort	genome-wide mapping of loci explaining variance in scrotal circumference in nellore cattle
description	The reproductive performance of bulls has a high impact on the beef cattle industry. Scrotal circumference (SC) is the most recorded reproductive trait in beef herds, and is used as a major selection criterion to improve precocity and fertility. The characterization of genomic regions affecting SC can contribute to the identification of diagnostic markers for reproductive performance and uncover molecular mechanisms underlying complex aspects of bovine reproductive biology. In this paper, we report a genome-wide scan for chromosome segments explaining differences in SC, using data of 861 Nellore bulls (Bos indicus) genotyped for over 777,000 single nucleotide polymorphisms. Loci that excel from the genome background were identified on chromosomes 4, 6, 7, 10, 14, 18 and 21. The majority of these regions were previously found to be associated with reproductive and body size traits in cattle. The signal on chromosome 14 replicates the pleiotropic quantitative trait locus encompassing PLAG1 that affects male fertility in cattle and stature in several species. Based on intensive literature mining, SP4, MAGEL2, SH3RF2, PDE5A and SNAI2 are proposed as novel candidate genes for SC, as they affect growth and testicular size in other animal models. These findings contribute to linking reproductive phenotypes to gene functions, and may offer new insights on the molecular biology of male fertility.
publisher	Public Library of Science
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928245/
_version_	1612059675469021184

Genome-Wide Mapping of Loci Explaining Variance in Scrotal Circumference in Nellore Cattle

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