T1-mapping in the heart: accuracy and precision
The longitudinal relaxation time constant (T1) of the myocardium is altered in various disease states due to increased water content or other changes to the local molecular environment. Changes in both native T1 and T1 following administration of gadolinium (Gd) based contrast agents are considered...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
BioMed Central
2014
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927683/ |
| id |
pubmed-3927683 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-39276832014-02-19 T1-mapping in the heart: accuracy and precision Kellman, Peter Hansen, Michael S Review The longitudinal relaxation time constant (T1) of the myocardium is altered in various disease states due to increased water content or other changes to the local molecular environment. Changes in both native T1 and T1 following administration of gadolinium (Gd) based contrast agents are considered important biomarkers and multiple methods have been suggested for quantifying myocardial T1 in vivo. Characterization of the native T1 of myocardial tissue may be used to detect and assess various cardiomyopathies while measurement of T1 with extracellular Gd based contrast agents provides additional information about the extracellular volume (ECV) fraction. The latter is particularly valuable for more diffuse diseases that are more challenging to detect using conventional late gadolinium enhancement (LGE). Both T1 and ECV measures have been shown to have important prognostic significance. BioMed Central 2014-01-04 /pmc/articles/PMC3927683/ /pubmed/24387626 http://dx.doi.org/10.1186/1532-429X-16-2 Text en Copyright © 2014 Kellman and Hansen; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Kellman, Peter Hansen, Michael S |
| spellingShingle |
Kellman, Peter Hansen, Michael S T1-mapping in the heart: accuracy and precision |
| author_facet |
Kellman, Peter Hansen, Michael S |
| author_sort |
Kellman, Peter |
| title |
T1-mapping in the heart: accuracy and precision |
| title_short |
T1-mapping in the heart: accuracy and precision |
| title_full |
T1-mapping in the heart: accuracy and precision |
| title_fullStr |
T1-mapping in the heart: accuracy and precision |
| title_full_unstemmed |
T1-mapping in the heart: accuracy and precision |
| title_sort |
t1-mapping in the heart: accuracy and precision |
| description |
The longitudinal relaxation time constant (T1) of the myocardium is altered in various disease states due to increased water content or other changes to the local molecular environment. Changes in both native T1 and T1 following administration of gadolinium (Gd) based contrast agents are considered important biomarkers and multiple methods have been suggested for quantifying myocardial T1 in vivo. Characterization of the native T1 of myocardial tissue may be used to detect and assess various cardiomyopathies while measurement of T1 with extracellular Gd based contrast agents provides additional information about the extracellular volume (ECV) fraction. The latter is particularly valuable for more diffuse diseases that are more challenging to detect using conventional late gadolinium enhancement (LGE). Both T1 and ECV measures have been shown to have important prognostic significance. |
| publisher |
BioMed Central |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927683/ |
| _version_ |
1612059527992049664 |