Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype

Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype

Here, we showed that the secretome of senescent melanoma cells drives basal melanoma cells towards a mesenchymal phenotype, with characteristic of stems illustrated by increased level of the prototype genes FN1, SNAIL, OCT4 and NANOG. This molecular reprogramming leads to an increase in the low-MITF...

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Bibliographic Details
Main Authors: Ohanna, Mickaël, Cheli, Yann, Bonet, Caroline, Bonazzi, Vanessa F, Allegra, Marylin, Giuliano, Sandy, Bille, Karine, Bahadoran, Philippe, Giacchero, Damien, Lacour, Jean Philippe, Boyle, Glen M, Hayward, Nicholas F, Bertolotto, Corine, Ballotti, Robert
Format: Online
Language:English
Published: Impact Journals LLC 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926821/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926821/

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