Topoisomerase I as a Biomarker: Detection of Activity at the Single Molecule Level
Human topoisomerase I (hTopI) is an essential cellular enzyme. The enzyme is often upregulated in cancer cells, and it is a target for chemotherapeutic drugs of the camptothecin (CPT) family. Response to CPT-based treatment is dependent on hTopI activity, and reduction in activity, and mutations in...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Molecular Diversity Preservation International (MDPI)
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926610/ |