Does regulation of skeletal muscle function involve circulating microRNAs?
MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation. Recently, growing evidence has shown that miRNAs are taken in by intracellular exosomes, secreted into circulation, and taken up by other cells. Circulating levels of several miRNAs are changed in diseases...
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Frontiers Media S.A.
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925823/ |
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pubmed-3925823 |
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pubmed-39258232014-03-04 Does regulation of skeletal muscle function involve circulating microRNAs? Aoi, Wataru Sakuma, Kunihiro Physiology MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation. Recently, growing evidence has shown that miRNAs are taken in by intracellular exosomes, secreted into circulation, and taken up by other cells. Circulating levels of several miRNAs are changed in diseases such as cancer, diabetes, and cardiovascular diseases; therefore, they are suggested to regulate functions of the recipient cells by modulating protein expression. Circulating miRNAs (c-miRNAs) may also modulate skeletal muscle function in physiological and pathological conditions. It has been suggested that acute and chronic exercise transiently or adaptively changes the level of c-miRNAs, thus post-transcriptionally regulating proteins associated with energy metabolism, myogenesis, and angiogenesis. Circulating levels of several miRNAs that are enriched in muscle are altered in muscle disorders and may be involved in their development and progression. In addition, such c-miRNAs may be useful as biomarkers to determine various interactions between tissues and also to reflect athletic performance, physical fatigue, incidence risk, and development of diseases. Frontiers Media S.A. 2014-02-17 /pmc/articles/PMC3925823/ /pubmed/24596559 http://dx.doi.org/10.3389/fphys.2014.00039 Text en Copyright © 2014 Aoi and Sakuma. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Aoi, Wataru Sakuma, Kunihiro |
| spellingShingle |
Aoi, Wataru Sakuma, Kunihiro Does regulation of skeletal muscle function involve circulating microRNAs? |
| author_facet |
Aoi, Wataru Sakuma, Kunihiro |
| author_sort |
Aoi, Wataru |
| title |
Does regulation of skeletal muscle function involve circulating microRNAs? |
| title_short |
Does regulation of skeletal muscle function involve circulating microRNAs? |
| title_full |
Does regulation of skeletal muscle function involve circulating microRNAs? |
| title_fullStr |
Does regulation of skeletal muscle function involve circulating microRNAs? |
| title_full_unstemmed |
Does regulation of skeletal muscle function involve circulating microRNAs? |
| title_sort |
does regulation of skeletal muscle function involve circulating micrornas? |
| description |
MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation. Recently, growing evidence has shown that miRNAs are taken in by intracellular exosomes, secreted into circulation, and taken up by other cells. Circulating levels of several miRNAs are changed in diseases such as cancer, diabetes, and cardiovascular diseases; therefore, they are suggested to regulate functions of the recipient cells by modulating protein expression. Circulating miRNAs (c-miRNAs) may also modulate skeletal muscle function in physiological and pathological conditions. It has been suggested that acute and chronic exercise transiently or adaptively changes the level of c-miRNAs, thus post-transcriptionally regulating proteins associated with energy metabolism, myogenesis, and angiogenesis. Circulating levels of several miRNAs that are enriched in muscle are altered in muscle disorders and may be involved in their development and progression. In addition, such c-miRNAs may be useful as biomarkers to determine various interactions between tissues and also to reflect athletic performance, physical fatigue, incidence risk, and development of diseases. |
| publisher |
Frontiers Media S.A. |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925823/ |
| _version_ |
1612058897741250560 |