Autophagy Therapeutic Potential of Garlic in Human Cancer Therapy

Cancer is one of the deadliest diseases against humans. To tackle this menace, humans have developed several high-technology therapies, such as chemotherapy, tomotherapy, targeted therapy, and antibody therapy. However, all these therapies have their own adverse side effects. Therefore, recent years...

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Main Authors:	Chu, Yung-Lin, Raghu, Rajasekaran, Lu, Kuan-Hung, Liu, Chun-Ting, Lin, Shu-Hsi, Lai, Yi-Syuan, Cheng, Wei-Cheng, Lin, Shih-Hang, Sheen, Lee-Yan
Format:	Online
Language:	English
Published:	Medknow Publications & Media Pvt Ltd 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924985/

id	pubmed-3924985
recordtype	oai_dc
spelling	pubmed-39249852014-04-08 Autophagy Therapeutic Potential of Garlic in Human Cancer Therapy Chu, Yung-Lin Raghu, Rajasekaran Lu, Kuan-Hung Liu, Chun-Ting Lin, Shu-Hsi Lai, Yi-Syuan Cheng, Wei-Cheng Lin, Shih-Hang Sheen, Lee-Yan Review Article Cancer is one of the deadliest diseases against humans. To tackle this menace, humans have developed several high-technology therapies, such as chemotherapy, tomotherapy, targeted therapy, and antibody therapy. However, all these therapies have their own adverse side effects. Therefore, recent years have seen increased attention being given to the natural food for complementary therapy, which have less side effects. Garlic (Dà Suàn; Allium sativum), is one of most powerful food used in many of the civilizations for both culinary and medicinal purpose. In general, these foods induce cancer cell death by apoptosis, autophagy, or necrosis. Studies have discussed how natural food factors regulate cell survival or death by autophagy in cancer cells. From many literature reviews, garlic could not only induce apoptosis but also autophagy in cancer cells. Autophagy, which is called type-II programmed cell death, provides new strategy in cancer therapy. In conclusion, we wish that garlic could be the pioneer food of complementary therapy in clinical cancer treatment and increase the life quality of cancer patients. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3924985/ /pubmed/24716172 http://dx.doi.org/10.4103/2225-4110.114895 Text en Copyright: © Journal of Traditional and Complementary Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Chu, Yung-Lin Raghu, Rajasekaran Lu, Kuan-Hung Liu, Chun-Ting Lin, Shu-Hsi Lai, Yi-Syuan Cheng, Wei-Cheng Lin, Shih-Hang Sheen, Lee-Yan
spellingShingle	Chu, Yung-Lin Raghu, Rajasekaran Lu, Kuan-Hung Liu, Chun-Ting Lin, Shu-Hsi Lai, Yi-Syuan Cheng, Wei-Cheng Lin, Shih-Hang Sheen, Lee-Yan Autophagy Therapeutic Potential of Garlic in Human Cancer Therapy
author_facet	Chu, Yung-Lin Raghu, Rajasekaran Lu, Kuan-Hung Liu, Chun-Ting Lin, Shu-Hsi Lai, Yi-Syuan Cheng, Wei-Cheng Lin, Shih-Hang Sheen, Lee-Yan
author_sort	Chu, Yung-Lin
title	Autophagy Therapeutic Potential of Garlic in Human Cancer Therapy
title_short	Autophagy Therapeutic Potential of Garlic in Human Cancer Therapy
title_full	Autophagy Therapeutic Potential of Garlic in Human Cancer Therapy
title_fullStr	Autophagy Therapeutic Potential of Garlic in Human Cancer Therapy
title_full_unstemmed	Autophagy Therapeutic Potential of Garlic in Human Cancer Therapy
title_sort	autophagy therapeutic potential of garlic in human cancer therapy
description	Cancer is one of the deadliest diseases against humans. To tackle this menace, humans have developed several high-technology therapies, such as chemotherapy, tomotherapy, targeted therapy, and antibody therapy. However, all these therapies have their own adverse side effects. Therefore, recent years have seen increased attention being given to the natural food for complementary therapy, which have less side effects. Garlic (Dà Suàn; Allium sativum), is one of most powerful food used in many of the civilizations for both culinary and medicinal purpose. In general, these foods induce cancer cell death by apoptosis, autophagy, or necrosis. Studies have discussed how natural food factors regulate cell survival or death by autophagy in cancer cells. From many literature reviews, garlic could not only induce apoptosis but also autophagy in cancer cells. Autophagy, which is called type-II programmed cell death, provides new strategy in cancer therapy. In conclusion, we wish that garlic could be the pioneer food of complementary therapy in clinical cancer treatment and increase the life quality of cancer patients.
publisher	Medknow Publications & Media Pvt Ltd
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924985/
_version_	1612058603204640768

Autophagy Therapeutic Potential of Garlic in Human Cancer Therapy

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