Root maturation and dentin–pulp response to enamel matrix derivative in pulpotomized permanent teeth

The success of pulpotomy of young permanent teeth depends on the proper selection of dressing materials. This study aimed to evaluate the histological and histomorphometric response of dentin–pulp complex to the enamel matrix derivative (Emdogain® gel) compared to that of calcium hydroxide when used...

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Main Authors:	Darwish, Sherif S, Abd El Meguid, Shadia H, Wahba, Nadia A, Mohamed, Ahmed A-R, Chrzanowski, Wojciech, Abou Neel, Ensanya A
Format:	Online
Language:	English
Published:	SAGE Publications 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924881/

id	pubmed-3924881
recordtype	oai_dc
spelling	pubmed-39248812014-02-18 Root maturation and dentin–pulp response to enamel matrix derivative in pulpotomized permanent teeth Darwish, Sherif S Abd El Meguid, Shadia H Wahba, Nadia A Mohamed, Ahmed A-R Chrzanowski, Wojciech Abou Neel, Ensanya A Article The success of pulpotomy of young permanent teeth depends on the proper selection of dressing materials. This study aimed to evaluate the histological and histomorphometric response of dentin–pulp complex to the enamel matrix derivative (Emdogain® gel) compared to that of calcium hydroxide when used as a pulp dressing in immature young permanent dogs’ teeth. Dentin-like tissues bridging the full width of the coronal pulp at the interface between the injured and healthy pulp tissues were seen after 1 month in both groups. With time, the dentin bridge increased in thickness for calcium hydroxide but disintegrated and fully disappeared for Emdogain-treated group. Progressive inflammation and total pulp degeneration were only evident with Emdogain-treated group. The root apices of Emdogain-treated teeth became matured and closed by cementum that attached to new alveolar bone by a well-oriented periodontal ligament. In young permanent dentition, Emdogain could be a good candidate for periodontium but not dentino–pulpal complex regeneration. SAGE Publications 2014-01-31 /pmc/articles/PMC3924881/ /pubmed/24551447 http://dx.doi.org/10.1177/2041731414521707 Text en © The Author(s) 2014
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Darwish, Sherif S Abd El Meguid, Shadia H Wahba, Nadia A Mohamed, Ahmed A-R Chrzanowski, Wojciech Abou Neel, Ensanya A
spellingShingle	Darwish, Sherif S Abd El Meguid, Shadia H Wahba, Nadia A Mohamed, Ahmed A-R Chrzanowski, Wojciech Abou Neel, Ensanya A Root maturation and dentin–pulp response to enamel matrix derivative in pulpotomized permanent teeth
author_facet	Darwish, Sherif S Abd El Meguid, Shadia H Wahba, Nadia A Mohamed, Ahmed A-R Chrzanowski, Wojciech Abou Neel, Ensanya A
author_sort	Darwish, Sherif S
title	Root maturation and dentin–pulp response to enamel matrix derivative in pulpotomized permanent teeth
title_short	Root maturation and dentin–pulp response to enamel matrix derivative in pulpotomized permanent teeth
title_full	Root maturation and dentin–pulp response to enamel matrix derivative in pulpotomized permanent teeth
title_fullStr	Root maturation and dentin–pulp response to enamel matrix derivative in pulpotomized permanent teeth
title_full_unstemmed	Root maturation and dentin–pulp response to enamel matrix derivative in pulpotomized permanent teeth
title_sort	root maturation and dentin–pulp response to enamel matrix derivative in pulpotomized permanent teeth
description	The success of pulpotomy of young permanent teeth depends on the proper selection of dressing materials. This study aimed to evaluate the histological and histomorphometric response of dentin–pulp complex to the enamel matrix derivative (Emdogain® gel) compared to that of calcium hydroxide when used as a pulp dressing in immature young permanent dogs’ teeth. Dentin-like tissues bridging the full width of the coronal pulp at the interface between the injured and healthy pulp tissues were seen after 1 month in both groups. With time, the dentin bridge increased in thickness for calcium hydroxide but disintegrated and fully disappeared for Emdogain-treated group. Progressive inflammation and total pulp degeneration were only evident with Emdogain-treated group. The root apices of Emdogain-treated teeth became matured and closed by cementum that attached to new alveolar bone by a well-oriented periodontal ligament. In young permanent dentition, Emdogain could be a good candidate for periodontium but not dentino–pulpal complex regeneration.
publisher	SAGE Publications
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924881/
_version_	1612058566815907840

Root maturation and dentin–pulp response to enamel matrix derivative in pulpotomized permanent teeth

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