A Monoallelic Deletion of the TcCRT Gene Increases the Attenuation of a Cultured Trypanosoma cruzi Strain, Protecting against an In Vivo Virulent Challenge

A Monoallelic Deletion of the TcCRT Gene Increases the Attenuation of a Cultured Trypanosoma cruzi Strain, Protecting against an In Vivo Virulent Challenge

Trypanosoma cruzi calreticulin (TcCRT) is a virulence factor that binds complement C1, thus inhibiting the activation of the classical complement pathway and generating pro-phagocytic signals that increase parasite infectivity. In a previous work, we characterized a clonal cell line lacking one TcC...

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Bibliographic Details
Main Authors: Sánchez-Valdéz, Fernando J., Pérez Brandán, Cecilia, Ramírez, Galia, Uncos, Alejandro D., Zago, M. Paola, Cimino, Rubén O., Cardozo, Rubén M., Marco, Jorge D., Ferreira, Arturo, Basombrío, Miguel Ángel
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923724/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923724/

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