Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits

The aim of this research was to evaluate the process of bone regeneration in rabbits, using chitosan and beta-tricalcium phosphate (β-TCP) independently and in combination. A total of 12 New Zealand rabbits of both sexes, with average weight of 3.0 ± 0.57 kg were used. Animals were randomly divided...

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Main Authors:	Azevedo, A. S., Sá, M. J. C., Fook, M. V. L., Neto, P. I. Nóbrega, Sousa, O. B., Azevedo, S. S., Teixeira, M. W., Costa, F. S., Araújo, A. L.
Format:	Online
Language:	English
Published:	Springer US 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921445/

id	pubmed-3921445
recordtype	oai_dc
spelling	pubmed-39214452014-02-19 Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits Azevedo, A. S. Sá, M. J. C. Fook, M. V. L. Neto, P. I. Nóbrega Sousa, O. B. Azevedo, S. S. Teixeira, M. W. Costa, F. S. Araújo, A. L. Article The aim of this research was to evaluate the process of bone regeneration in rabbits, using chitosan and beta-tricalcium phosphate (β-TCP) independently and in combination. A total of 12 New Zealand rabbits of both sexes, with average weight of 3.0 ± 0.57 kg were used. Animals were randomly divided into two experimental time points, with six animals euthanized 45 days after surgery and six euthanized 90 days after surgery. We performed two osteotomies in each tibia. The left tibia was used for the chitosan (QUI) and control groups, and the right tibia was used for the β-TCP alone and in combination with chitosan (QUI+TCP) groups. Tomographic evaluation showed no statistically significant difference among groups; however radiopacity was higher in the treated groups. Comparative descriptive histological evaluation found that treatment groups stimulated a more pronounced tissue repair reaction and accelerated bone repair. Morphometric analysis showed that treatment groups presented statistically higher bone formation compared with the control group. Springer US 2013-11-17 2014 /pmc/articles/PMC3921445/ /pubmed/24243224 http://dx.doi.org/10.1007/s10856-013-5091-2 Text en © The Author(s) 2013 Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Azevedo, A. S. Sá, M. J. C. Fook, M. V. L. Neto, P. I. Nóbrega Sousa, O. B. Azevedo, S. S. Teixeira, M. W. Costa, F. S. Araújo, A. L.
spellingShingle	Azevedo, A. S. Sá, M. J. C. Fook, M. V. L. Neto, P. I. Nóbrega Sousa, O. B. Azevedo, S. S. Teixeira, M. W. Costa, F. S. Araújo, A. L. Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits
author_facet	Azevedo, A. S. Sá, M. J. C. Fook, M. V. L. Neto, P. I. Nóbrega Sousa, O. B. Azevedo, S. S. Teixeira, M. W. Costa, F. S. Araújo, A. L.
author_sort	Azevedo, A. S.
title	Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits
title_short	Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits
title_full	Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits
title_fullStr	Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits
title_full_unstemmed	Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits
title_sort	use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits
description	The aim of this research was to evaluate the process of bone regeneration in rabbits, using chitosan and beta-tricalcium phosphate (β-TCP) independently and in combination. A total of 12 New Zealand rabbits of both sexes, with average weight of 3.0 ± 0.57 kg were used. Animals were randomly divided into two experimental time points, with six animals euthanized 45 days after surgery and six euthanized 90 days after surgery. We performed two osteotomies in each tibia. The left tibia was used for the chitosan (QUI) and control groups, and the right tibia was used for the β-TCP alone and in combination with chitosan (QUI+TCP) groups. Tomographic evaluation showed no statistically significant difference among groups; however radiopacity was higher in the treated groups. Comparative descriptive histological evaluation found that treatment groups stimulated a more pronounced tissue repair reaction and accelerated bone repair. Morphometric analysis showed that treatment groups presented statistically higher bone formation compared with the control group.
publisher	Springer US
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921445/
_version_	1612057402361774080

Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits

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