BRK Targets Dok1 for Ubiquitin-Mediated Proteasomal Degradation to Promote Cell Proliferation and Migration

BRK Targets Dok1 for Ubiquitin-Mediated Proteasomal Degradation to Promote Cell Proliferation and Migration

Breast tumor kinase (BRK), also known as protein tyrosine kinase 6 (PTK6), is a non-receptor tyrosine kinase overexpressed in more that 60% of human breast carcinomas. The overexpression of BRK has been shown to sensitize mammary epithelial cells to mitogenic signaling and to promote cell prolifera...

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Bibliographic Details
Main Authors: Miah, Sayem, Goel, Raghuveera Kumar, Dai, Chenlu, Kalra, Natasha, Beaton-Brown, Erika, Bagu, Edward T., Bonham, Keith, Lukong, Kiven E.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921129/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921129/

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