Using multiple genetic variants as instrumental variables for modifiable risk factors

Using multiple genetic variants as instrumental variables for modifiable risk factors

Mendelian randomisation analyses use genetic variants as instrumental variables (IVs) to estimate causal effects of modifiable risk factors on disease outcomes. Genetic variants typically explain a small proportion of the variability in risk factors; hence Mendelian randomisation analyses can requir...

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Bibliographic Details
Main Authors: Palmer, Tom M, Lawlor, Debbie A, Harbord, Roger M, Sheehan, Nuala A, Tobias, Jon H, Timpson, Nicholas J, Smith, George Davey, Sterne, Jonathan AC
Format: Online
Language:English
Published: SAGE Publications 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917707/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917707/

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