Lipogenic gene expression profile in patients with gastric cancer
Numerous types of cancer exhibit increased lipogenesis and expression of lipogenic enzymes and transcription factors, including sterol regulatory element-binding protein-1. Lipogenic gene expression is upregulated at the mRNA level, in concert with metabolic pathways associated with changes in expre...
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| Format: | Online |
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D.A. Spandidos
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915680/ |
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pubmed-3915680 |
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pubmed-39156802014-03-19 Lipogenic gene expression profile in patients with gastric cancer MIYACHI, KAZUHITO SAWADA, YOUKI SHIDA, YOSUKE SUGAWARA, AKIRA HISATOMI, HISASHI Articles Numerous types of cancer exhibit increased lipogenesis and expression of lipogenic enzymes and transcription factors, including sterol regulatory element-binding protein-1. Lipogenic gene expression is upregulated at the mRNA level, in concert with metabolic pathways associated with changes in expression and/or activity of lipogenic transcription factors. However, this expression pattern in human gastric carcinoma has not been elucidated. In this study, lipogenic gene expression in cancer tissues was investigated using quantitative PCR. In patients with gastric cancer, carnitine O-palmitoyltransferase type I mRNA and miR-33b were significantly downregulated, suggesting that miR-33b downregulation is mediated by conditions that also affect the expression and/or activity of transcription factors involved in lipogenic gene expression. Consequently, the association between miR-33b and gastric cancer may provide a novel strategy for the genetic diagnosis of gastric cancer. However, additional studies including a larger number of samples are required to confirm these results. D.A. Spandidos 2013-09 2013-07-17 /pmc/articles/PMC3915680/ /pubmed/24649254 http://dx.doi.org/10.3892/mco.2013.148 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
MIYACHI, KAZUHITO SAWADA, YOUKI SHIDA, YOSUKE SUGAWARA, AKIRA HISATOMI, HISASHI |
| spellingShingle |
MIYACHI, KAZUHITO SAWADA, YOUKI SHIDA, YOSUKE SUGAWARA, AKIRA HISATOMI, HISASHI Lipogenic gene expression profile in patients with gastric cancer |
| author_facet |
MIYACHI, KAZUHITO SAWADA, YOUKI SHIDA, YOSUKE SUGAWARA, AKIRA HISATOMI, HISASHI |
| author_sort |
MIYACHI, KAZUHITO |
| title |
Lipogenic gene expression profile in patients with gastric cancer |
| title_short |
Lipogenic gene expression profile in patients with gastric cancer |
| title_full |
Lipogenic gene expression profile in patients with gastric cancer |
| title_fullStr |
Lipogenic gene expression profile in patients with gastric cancer |
| title_full_unstemmed |
Lipogenic gene expression profile in patients with gastric cancer |
| title_sort |
lipogenic gene expression profile in patients with gastric cancer |
| description |
Numerous types of cancer exhibit increased lipogenesis and expression of lipogenic enzymes and transcription factors, including sterol regulatory element-binding protein-1. Lipogenic gene expression is upregulated at the mRNA level, in concert with metabolic pathways associated with changes in expression and/or activity of lipogenic transcription factors. However, this expression pattern in human gastric carcinoma has not been elucidated. In this study, lipogenic gene expression in cancer tissues was investigated using quantitative PCR. In patients with gastric cancer, carnitine O-palmitoyltransferase type I mRNA and miR-33b were significantly downregulated, suggesting that miR-33b downregulation is mediated by conditions that also affect the expression and/or activity of transcription factors involved in lipogenic gene expression. Consequently, the association between miR-33b and gastric cancer may provide a novel strategy for the genetic diagnosis of gastric cancer. However, additional studies including a larger number of samples are required to confirm these results. |
| publisher |
D.A. Spandidos |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915680/ |
| _version_ |
1612055637419622400 |