Chromosomal Copy Number Aberrations in Colorectal Metastases Resemble Their Primary Counterparts and Differences Are Typically Non-Recurrent
The metastatic process is complex and remains a major obstacle in the management of colorectal cancer. To gain a better insight into the pathology of metastasis, we investigated genomic aberrations in a large cohort of matched colorectal cancer primaries and distant metastases from various sites by...
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Public Library of Science
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914793/ |
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pubmed-39147932014-02-06 Chromosomal Copy Number Aberrations in Colorectal Metastases Resemble Their Primary Counterparts and Differences Are Typically Non-Recurrent Mekenkamp, Leonie J. M. Haan, Josien C. Israeli, Daniëlle van Essen, Hendrik F. B. Dijkstra, Jeroen R. van Cleef, Patricia Punt, Cornelis J. A. Meijer, Gerrit A. Nagtegaal, Iris D. Ylstra, Bauke Research Article The metastatic process is complex and remains a major obstacle in the management of colorectal cancer. To gain a better insight into the pathology of metastasis, we investigated genomic aberrations in a large cohort of matched colorectal cancer primaries and distant metastases from various sites by high resolution array comparative genomic hybridization. In total, 62 primary colorectal cancers, and 68 matched metastases (22 liver, 11 lung, 12 ovary, 12 omentum, and 11 distant lymph nodes) were analyzed. Public datasets were used for validation purposes. Metastases resemble their matched primary tumors in the majority of the patients. This validates the significant overlap in chromosomal aberrations between primary tumors and corresponding metastases observed previously. We observed 15 statistically significant different regions between the primary tumors and their matched metastases, of which only one recurrent event in metastases was observed. We conclude, based on detailed analysis and large independent datasets, that chromosomal copy number aberrations in colorectal metastases resemble their primary counterparts, and differences are typically non-recurrent. Public Library of Science 2014-02-05 /pmc/articles/PMC3914793/ /pubmed/24505270 http://dx.doi.org/10.1371/journal.pone.0086833 Text en © 2014 Mekenkamp et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Mekenkamp, Leonie J. M. Haan, Josien C. Israeli, Daniëlle van Essen, Hendrik F. B. Dijkstra, Jeroen R. van Cleef, Patricia Punt, Cornelis J. A. Meijer, Gerrit A. Nagtegaal, Iris D. Ylstra, Bauke |
| spellingShingle |
Mekenkamp, Leonie J. M. Haan, Josien C. Israeli, Daniëlle van Essen, Hendrik F. B. Dijkstra, Jeroen R. van Cleef, Patricia Punt, Cornelis J. A. Meijer, Gerrit A. Nagtegaal, Iris D. Ylstra, Bauke Chromosomal Copy Number Aberrations in Colorectal Metastases Resemble Their Primary Counterparts and Differences Are Typically Non-Recurrent |
| author_facet |
Mekenkamp, Leonie J. M. Haan, Josien C. Israeli, Daniëlle van Essen, Hendrik F. B. Dijkstra, Jeroen R. van Cleef, Patricia Punt, Cornelis J. A. Meijer, Gerrit A. Nagtegaal, Iris D. Ylstra, Bauke |
| author_sort |
Mekenkamp, Leonie J. M. |
| title |
Chromosomal Copy Number Aberrations in Colorectal Metastases Resemble Their Primary Counterparts and Differences Are Typically Non-Recurrent |
| title_short |
Chromosomal Copy Number Aberrations in Colorectal Metastases Resemble Their Primary Counterparts and Differences Are Typically Non-Recurrent |
| title_full |
Chromosomal Copy Number Aberrations in Colorectal Metastases Resemble Their Primary Counterparts and Differences Are Typically Non-Recurrent |
| title_fullStr |
Chromosomal Copy Number Aberrations in Colorectal Metastases Resemble Their Primary Counterparts and Differences Are Typically Non-Recurrent |
| title_full_unstemmed |
Chromosomal Copy Number Aberrations in Colorectal Metastases Resemble Their Primary Counterparts and Differences Are Typically Non-Recurrent |
| title_sort |
chromosomal copy number aberrations in colorectal metastases resemble their primary counterparts and differences are typically non-recurrent |
| description |
The metastatic process is complex and remains a major obstacle in the management of colorectal cancer. To gain a better insight into the pathology of metastasis, we investigated genomic aberrations in a large cohort of matched colorectal cancer primaries and distant metastases from various sites by high resolution array comparative genomic hybridization. In total, 62 primary colorectal cancers, and 68 matched metastases (22 liver, 11 lung, 12 ovary, 12 omentum, and 11 distant lymph nodes) were analyzed. Public datasets were used for validation purposes. Metastases resemble their matched primary tumors in the majority of the patients. This validates the significant overlap in chromosomal aberrations between primary tumors and corresponding metastases observed previously. We observed 15 statistically significant different regions between the primary tumors and their matched metastases, of which only one recurrent event in metastases was observed. We conclude, based on detailed analysis and large independent datasets, that chromosomal copy number aberrations in colorectal metastases resemble their primary counterparts, and differences are typically non-recurrent. |
| publisher |
Public Library of Science |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914793/ |
| _version_ |
1612055256174166016 |