Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model

Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model

The t(8;21) chromosomal translocation activates aberrant expression of the AML1-ETO (AE) fusion protein and is commonly associated with core binding factor acute myeloid leukaemia (CBF AML). Combining a conditional mouse model that closely resembles the slow evolution and the mosaic AE expression pa...

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Bibliographic Details
Main Authors: Cabezas-Wallscheid, Nina, Eichwald, Victoria, de Graaf, Jos, Löwer, Martin, Lehr, Hans-Anton, Kreft, Andreas, Eshkind, Leonid, Hildebrandt, Andreas, Abassi, Yasmin, Heck, Rosario, Dehof, Anna Katharina, Ohngemach, Svetlana, Sprengel, Rolf, Wörtge, Simone, Schmitt, Steffen, Lotz, Johannes, Meyer, Claudius, Kindler, Thomas, Zhang, Dong-Er, Kaina, Bernd, Castle, John C, Trumpp, Andreas, Sahin, Ugur, Bockamp, Ernesto
Format: Online
Language:English
Published: John Wiley and Sons 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914523/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914523/

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