Proteostasis and longevity: when does aging really begin?

Aging is a complex process regulated by multiple cellular pathways, including the proteostasis network. The proteostasis network consists of molecular chaperones, stress-response transcription factors, and protein degradation machines that sense and respond to proteotoxic stress and protein misfoldi...

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Bibliographic Details
Main Authors: Labbadia, John, Morimoto, Richard I.
Format: Online
Language:English
Published: Faculty of 1000 Ltd 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914504/