Meibomian Gland Dysfunction: Endocrine Aspects

Meibomian Gland Dysfunction: Endocrine Aspects

Purpose. To compare the hormone levels of patients with seborrheic meibomian gland dysfunction with controls. Procedures. This is a retrospective case-control study involving 50 patients and 50 controls. Blood workup for hormones was studied in both groups by using macroELISA (enzyme-linked immunos...

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Main Authors: Sahin, Ozlem G., Kartal, Elçin, Taheri, Nusret
Format: Online
Language:English
Published: International Scholarly Research Network 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912588/
id pubmed-3912588
recordtype oai_dc
spelling pubmed-39125882014-02-16 Meibomian Gland Dysfunction: Endocrine Aspects Sahin, Ozlem G. Kartal, Elçin Taheri, Nusret Clinical Study Purpose. To compare the hormone levels of patients with seborrheic meibomian gland dysfunction with controls. Procedures. This is a retrospective case-control study involving 50 patients and 50 controls. Blood workup for hormones was studied in both groups by using macroELISA (enzyme-linked immunosorbent assay). Statistical evaluation was done by using SPSS 15.0 independent samples t-test. Results. There were statistically significant differences of serum testosterone and dehydroepiandrosterone sulphate levels between patients and controls (P = 0.000). Female gender showed statistically significant differences of serum thyroid-stimulating hormone and prolactin levels between patients and controls (P = 0.014 and P = 0.043), in addition to serum testosterone and dehydroepiandrosterone sulphate levels (P = 0.000 and P = 0.001). However, male gender showed statistically significant differences of only serum testosterone and dehydroepiandrosterone sulphate levels between patients and controls. (P = 0.003 and P = 0.003 resp.). Conclusions. Increased serum levels of testosterone and dehydroepiandrosterone sulphate in both genders should be considered as diagnostic markers for seborrheic meibomian gland dysfunction. International Scholarly Research Network 2011-10-20 /pmc/articles/PMC3912588/ /pubmed/24533183 http://dx.doi.org/10.5402/2011/465198 Text en Copyright © 2011 Ozlem G. Sahin et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Sahin, Ozlem G.
Kartal, Elçin
Taheri, Nusret
spellingShingle Sahin, Ozlem G.
Kartal, Elçin
Taheri, Nusret
Meibomian Gland Dysfunction: Endocrine Aspects
author_facet Sahin, Ozlem G.
Kartal, Elçin
Taheri, Nusret
author_sort Sahin, Ozlem G.
title Meibomian Gland Dysfunction: Endocrine Aspects
title_short Meibomian Gland Dysfunction: Endocrine Aspects
title_full Meibomian Gland Dysfunction: Endocrine Aspects
title_fullStr Meibomian Gland Dysfunction: Endocrine Aspects
title_full_unstemmed Meibomian Gland Dysfunction: Endocrine Aspects
title_sort meibomian gland dysfunction: endocrine aspects
description Purpose. To compare the hormone levels of patients with seborrheic meibomian gland dysfunction with controls. Procedures. This is a retrospective case-control study involving 50 patients and 50 controls. Blood workup for hormones was studied in both groups by using macroELISA (enzyme-linked immunosorbent assay). Statistical evaluation was done by using SPSS 15.0 independent samples t-test. Results. There were statistically significant differences of serum testosterone and dehydroepiandrosterone sulphate levels between patients and controls (P = 0.000). Female gender showed statistically significant differences of serum thyroid-stimulating hormone and prolactin levels between patients and controls (P = 0.014 and P = 0.043), in addition to serum testosterone and dehydroepiandrosterone sulphate levels (P = 0.000 and P = 0.001). However, male gender showed statistically significant differences of only serum testosterone and dehydroepiandrosterone sulphate levels between patients and controls. (P = 0.003 and P = 0.003 resp.). Conclusions. Increased serum levels of testosterone and dehydroepiandrosterone sulphate in both genders should be considered as diagnostic markers for seborrheic meibomian gland dysfunction.
publisher International Scholarly Research Network
publishDate 2011
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912588/
_version_ 1612054321962156032

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