Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction via modulation of glutamate receptor recycling in Down syndrome

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction via modulation of glutamate receptor recycling in Down syndrome

Sorting nexin 27 (SNX27), a brain-enriched PDZ domain protein, regulates endocytic sorting and trafficking. Here, we show that Snx27−/− mice exhibit severe neuronal deficits in the hippocampus and cortex. While Snx27+/− mice exhibit grossly normal neuroanatomy, we find defects in synaptic function,...

Full description

Bibliographic Details
Main Authors: Wang, Xin, Zhao, Yingjun, Zhang, Xiaofei, Badie, Hedieh, Zhou, Ying, Mu, Yangling, Loo, Li Shen, Cai, Lei, Thompson, Robert C., Yang, Bo, Chen, Yaomin, Johnson, Peter F., Wu, Chengbiao, Bu, Guojun, Mobley, William C., Zhang, Dongxian, Gage, Fred H., Ranscht, Barbara, Zhang, Yun-wu, Lipton, Stuart A., Hong, Wanjin, Xu, Huaxi
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911880/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911880/

Similar Items