Non-Target Activity Detection by Post-Radioembolization Yttrium-90 PET/CT: Image Assessment Technique and Case Examples

High resolution yttrium-90 (90Y) imaging of post-radioembolization microsphere biodistribution may be achieved by conventional positron emission tomography with integrated computed tomography (PET/CT) scanners that have time-of-flight capability. However, reconstructed 90Y PET/CT images have high ba...

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Main Authors:	Kao, Yung Hsiang, Tan, Andrew E. H., Lo, Richard H. G., Tay, Kiang Hiong, Tan, Bien Soo, Chow, Pierce K. H., Ng, David C. E., Goh, Anthony S. W.
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910080/

id	pubmed-3910080
recordtype	oai_dc
spelling	pubmed-39100802014-02-18 Non-Target Activity Detection by Post-Radioembolization Yttrium-90 PET/CT: Image Assessment Technique and Case Examples Kao, Yung Hsiang Tan, Andrew E. H. Lo, Richard H. G. Tay, Kiang Hiong Tan, Bien Soo Chow, Pierce K. H. Ng, David C. E. Goh, Anthony S. W. Oncology High resolution yttrium-90 (90Y) imaging of post-radioembolization microsphere biodistribution may be achieved by conventional positron emission tomography with integrated computed tomography (PET/CT) scanners that have time-of-flight capability. However, reconstructed 90Y PET/CT images have high background noise, making non-target activity detection technically challenging. This educational article describes our image assessment technique for non-target activity detection by 90Y PET/CT, which qualitatively overcomes the problem of background noise. We present selected case examples of non-target activity in untargeted liver, stomach, gallbladder, chest wall, and kidney, supported by angiography and 90Y bremsstrahlung single-photon emission computed tomography with integrated computed tomography (SPECT/CT) or technetium-99m macroaggregated albumin SPECT/CT. Frontiers Media S.A. 2014-02-03 /pmc/articles/PMC3910080/ /pubmed/24551594 http://dx.doi.org/10.3389/fonc.2014.00011 Text en Copyright © 2014 Kao, Tan, Lo, Tay, Tan, Chow, Ng and Goh. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kao, Yung Hsiang Tan, Andrew E. H. Lo, Richard H. G. Tay, Kiang Hiong Tan, Bien Soo Chow, Pierce K. H. Ng, David C. E. Goh, Anthony S. W.
spellingShingle	Kao, Yung Hsiang Tan, Andrew E. H. Lo, Richard H. G. Tay, Kiang Hiong Tan, Bien Soo Chow, Pierce K. H. Ng, David C. E. Goh, Anthony S. W. Non-Target Activity Detection by Post-Radioembolization Yttrium-90 PET/CT: Image Assessment Technique and Case Examples
author_facet	Kao, Yung Hsiang Tan, Andrew E. H. Lo, Richard H. G. Tay, Kiang Hiong Tan, Bien Soo Chow, Pierce K. H. Ng, David C. E. Goh, Anthony S. W.
author_sort	Kao, Yung Hsiang
title	Non-Target Activity Detection by Post-Radioembolization Yttrium-90 PET/CT: Image Assessment Technique and Case Examples
title_short	Non-Target Activity Detection by Post-Radioembolization Yttrium-90 PET/CT: Image Assessment Technique and Case Examples
title_full	Non-Target Activity Detection by Post-Radioembolization Yttrium-90 PET/CT: Image Assessment Technique and Case Examples
title_fullStr	Non-Target Activity Detection by Post-Radioembolization Yttrium-90 PET/CT: Image Assessment Technique and Case Examples
title_full_unstemmed	Non-Target Activity Detection by Post-Radioembolization Yttrium-90 PET/CT: Image Assessment Technique and Case Examples
title_sort	non-target activity detection by post-radioembolization yttrium-90 pet/ct: image assessment technique and case examples
description	High resolution yttrium-90 (90Y) imaging of post-radioembolization microsphere biodistribution may be achieved by conventional positron emission tomography with integrated computed tomography (PET/CT) scanners that have time-of-flight capability. However, reconstructed 90Y PET/CT images have high background noise, making non-target activity detection technically challenging. This educational article describes our image assessment technique for non-target activity detection by 90Y PET/CT, which qualitatively overcomes the problem of background noise. We present selected case examples of non-target activity in untargeted liver, stomach, gallbladder, chest wall, and kidney, supported by angiography and 90Y bremsstrahlung single-photon emission computed tomography with integrated computed tomography (SPECT/CT) or technetium-99m macroaggregated albumin SPECT/CT.
publisher	Frontiers Media S.A.
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910080/
_version_	1612053872641048576

Non-Target Activity Detection by Post-Radioembolization Yttrium-90 PET/CT: Image Assessment Technique and Case Examples

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