A thermodynamic assay to test pharmacological chaperones for Fabry disease☆
•Pharmacological chaperones stabilize the folded state of proteins.•Only some Fabry mutations can be treated with pharmacological chaperones.•Urea-induced unfolding represents a novel assay to test the efficiency of drugs.•The test with urea can be applied to a tiny amount of mutants in raw extracts...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Elsevier Pub. Co
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909460/ |