Excess CD40L does not rescue anti-DNA B cells from clonal anergy
CD40L, a member of the tumor necrosis factor (TNF) ligand family, is overexpressed in patients with systemic lupus erythematosus and in lupus mouse models. Previously, we demonstrated that B cells producing pathogenic anti-Sm/RNP antibodies are deleted in the splenic marginal zone (MZ), and that MZ...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
F1000Research
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907155/ |