Phylogenetic applications of whole Y-chromosome sequences and the Near Eastern origin of Ashkenazi Levites
Previous Y-chromosome studies have demonstrated that Ashkenazi Levites, members of a paternally inherited Jewish priestly caste, display a distinctive founder event within R1a, the most prevalent Y-chromosome haplogroup in Eastern Europe. Here we report the analysis of 16 whole R1 sequences and show...
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| Format: | Online |
| Language: | English |
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Nature Pub. Group
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905698/ |
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pubmed-39056982014-01-29 Phylogenetic applications of whole Y-chromosome sequences and the Near Eastern origin of Ashkenazi Levites Rootsi, Siiri Behar, Doron M. Järve, Mari Lin, Alice A. Myres, Natalie M. Passarelli, Ben Poznik, G. David Tzur, Shay Sahakyan, Hovhannes Pathak, Ajai Kumar Rosset, Saharon Metspalu, Mait Grugni, Viola Semino, Ornella Metspalu, Ene Bustamante, Carlos D. Skorecki, Karl Villems, Richard Kivisild, Toomas Underhill, Peter A. Article Previous Y-chromosome studies have demonstrated that Ashkenazi Levites, members of a paternally inherited Jewish priestly caste, display a distinctive founder event within R1a, the most prevalent Y-chromosome haplogroup in Eastern Europe. Here we report the analysis of 16 whole R1 sequences and show that a set of 19 unique nucleotide substitutions defines the Ashkenazi R1a lineage. While our survey of one of these, M582, in 2,834 R1a samples reveals its absence in 922 Eastern Europeans, we show it is present in all sampled R1a Ashkenazi Levites, as well as in 33.8% of other R1a Ashkenazi Jewish males and 5.9% of 303 R1a Near Eastern males, where it shows considerably higher diversity. Moreover, the M582 lineage also occurs at low frequencies in non-Ashkenazi Jewish populations. In contrast to the previously suggested Eastern European origin for Ashkenazi Levites, the current data are indicative of a geographic source of the Levite founder lineage in the Near East and its likely presence among pre-Diaspora Hebrews. Nature Pub. Group 2013-12-17 /pmc/articles/PMC3905698/ /pubmed/24346185 http://dx.doi.org/10.1038/ncomms3928 Text en Copyright © 2013, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Rootsi, Siiri Behar, Doron M. Järve, Mari Lin, Alice A. Myres, Natalie M. Passarelli, Ben Poznik, G. David Tzur, Shay Sahakyan, Hovhannes Pathak, Ajai Kumar Rosset, Saharon Metspalu, Mait Grugni, Viola Semino, Ornella Metspalu, Ene Bustamante, Carlos D. Skorecki, Karl Villems, Richard Kivisild, Toomas Underhill, Peter A. |
| spellingShingle |
Rootsi, Siiri Behar, Doron M. Järve, Mari Lin, Alice A. Myres, Natalie M. Passarelli, Ben Poznik, G. David Tzur, Shay Sahakyan, Hovhannes Pathak, Ajai Kumar Rosset, Saharon Metspalu, Mait Grugni, Viola Semino, Ornella Metspalu, Ene Bustamante, Carlos D. Skorecki, Karl Villems, Richard Kivisild, Toomas Underhill, Peter A. Phylogenetic applications of whole Y-chromosome sequences and the Near Eastern origin of Ashkenazi Levites |
| author_facet |
Rootsi, Siiri Behar, Doron M. Järve, Mari Lin, Alice A. Myres, Natalie M. Passarelli, Ben Poznik, G. David Tzur, Shay Sahakyan, Hovhannes Pathak, Ajai Kumar Rosset, Saharon Metspalu, Mait Grugni, Viola Semino, Ornella Metspalu, Ene Bustamante, Carlos D. Skorecki, Karl Villems, Richard Kivisild, Toomas Underhill, Peter A. |
| author_sort |
Rootsi, Siiri |
| title |
Phylogenetic applications of whole Y-chromosome sequences and the Near Eastern origin of Ashkenazi Levites |
| title_short |
Phylogenetic applications of whole Y-chromosome sequences and the Near Eastern origin of Ashkenazi Levites |
| title_full |
Phylogenetic applications of whole Y-chromosome sequences and the Near Eastern origin of Ashkenazi Levites |
| title_fullStr |
Phylogenetic applications of whole Y-chromosome sequences and the Near Eastern origin of Ashkenazi Levites |
| title_full_unstemmed |
Phylogenetic applications of whole Y-chromosome sequences and the Near Eastern origin of Ashkenazi Levites |
| title_sort |
phylogenetic applications of whole y-chromosome sequences and the near eastern origin of ashkenazi levites |
| description |
Previous Y-chromosome studies have demonstrated that Ashkenazi Levites, members of a paternally inherited Jewish priestly caste, display a distinctive founder event within R1a, the most prevalent Y-chromosome haplogroup in Eastern Europe. Here we report the analysis of 16 whole R1 sequences and show that a set of 19 unique nucleotide substitutions defines the Ashkenazi R1a lineage. While our survey of one of these, M582, in 2,834 R1a samples reveals its absence in 922 Eastern Europeans, we show it is present in all sampled R1a Ashkenazi Levites, as well as in 33.8% of other R1a Ashkenazi Jewish males and 5.9% of 303 R1a Near Eastern males, where it shows considerably higher diversity. Moreover, the M582 lineage also occurs at low frequencies in non-Ashkenazi Jewish populations. In contrast to the previously suggested Eastern European origin for Ashkenazi Levites, the current data are indicative of a geographic source of the Levite founder lineage in the Near East and its likely presence among pre-Diaspora Hebrews. |
| publisher |
Nature Pub. Group |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905698/ |
| _version_ |
1612052420168253440 |