CYP2D6 Genotype and Adjuvant Tamoxifen: Meta-Analysis of Heterogeneous Study Populations

CYP2D6 Genotype and Adjuvant Tamoxifen: Meta-Analysis of Heterogeneous Study Populations

The International Tamoxifen Pharmacogenomics Consortium was established to address the controversy regarding cytochrome P450 2D6 (CYP2D6) status and clinical outcomes in tamoxifen therapy. We performed a meta-analysis on data from 4,973 tamoxifen-treated patients (12 globally distributed sites). Usi...

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Main Authors: Province, M A, Goetz, M P, Brauch, H, Flockhart, D A, Hebert, J M, Whaley, R, Suman, V J, Schroth, W, Winter, S, Zembutsu, H, Mushiroda, T, Newman, W G, Lee, M-T M, Ambrosone, C B, Beckmann, M W, Choi, J-Y, Dieudonné, A-S, Fasching, P A, Ferraldeschi, R, Gong, L, Haschke-Becher, E, Howell, A, Jordan, L B, Hamann, U, Kiyotani, K, Krippl, P, Lambrechts, D, Latif, A, Langsenlehner, U, Lorizio, W, Neven, P, Nguyen, A T, Park, B-W, Purdie, C A, Quinlan, P, Renner, W, Schmidt, M, Schwab, M, Shin, J-G, Stingl, J C, Wegman, P, Wingren, S, Wu, A H B, Ziv, E, Zirpoli, G, Thompson, A M, Jordan, V C, Nakamura, Y, Altman, R B, Ames, M M, Weinshilboum, R M, Eichelbaum, M, Ingle, J N, Klein, T E
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904554/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904554/

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