Revisiting amino acid substitution matrices for identifying distantly related proteins

Motivation: Although many amino acid substitution matrices have been developed, it has not been well understood which is the best for similarity searches, especially for remote homology detection. Therefore, we collected information related to existing matrices, condensed it and derived a novel matr...

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Bibliographic Details
Main Authors: Yamada, Kazunori, Tomii, Kentaro
Format: Online
Language:English
Published: Oxford University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904525/