Cortical Dysfunction Underlies the Development of the Split-Hand in Amyotrophic Lateral Sclerosis

The split-hand phenomenon, a specific feature of amyotrophic lateral sclerosis (ALS), refers to preferential wasting of abductor pollicis brevis (APB) and first dorsal interosseous (FDI) with relative preservation of abductor digiti minimi (ADM). The pathophysiological mechanisms underlying the spli...

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Bibliographic Details
Main Authors: Menon, Parvathi, Kiernan, Matthew C., Vucic, Steve
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901749/