Genetic Variations in the Flanking Regions of miR-101-2 Are Associated with Increased Risk of Breast Cancer

Genetic variants in human microRNA (miRNA) genes may alter mature miRNA processing and/or target selection, and likely contribute to cancer susceptibility and disease progression. Previous studies have suggested that miR-101 may play important roles in the development of cancer by regulating key tum...

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Main Authors:	Chen, Jiaping, Qin, Zhenzhen, Jiang, Yue, Wang, Yanru, He, Yisha, Dai, Juncheng, Jin, Guangfu, Ma, Hongxia, Hu, Zhibin, Yin, Yongmei, Shen, Hongbing
Format:	Online
Language:	English
Published:	Public Library of Science 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901682/

id	pubmed-3901682
recordtype	oai_dc
spelling	pubmed-39016822014-01-28 Genetic Variations in the Flanking Regions of miR-101-2 Are Associated with Increased Risk of Breast Cancer Chen, Jiaping Qin, Zhenzhen Jiang, Yue Wang, Yanru He, Yisha Dai, Juncheng Jin, Guangfu Ma, Hongxia Hu, Zhibin Yin, Yongmei Shen, Hongbing Research Article Genetic variants in human microRNA (miRNA) genes may alter mature miRNA processing and/or target selection, and likely contribute to cancer susceptibility and disease progression. Previous studies have suggested that miR-101 may play important roles in the development of cancer by regulating key tumor-associated genes. However, the role of single nucleotide polymorphisms (SNPs) of miR-101 in breast cancer susceptibility remains unclear. In this study, we genotyped 11 SNPs of the miR-101 genes (including miR-101-1 and miR-101-2) in a case-control study of 1064 breast cancer cases and 1073 cancer-free controls. The results revealed that rs462480 and rs1053872 in the flank regions of pre-miR-101-2 were significantly associated with increased risk of breast cancer (rs462480 AC/CC vs AA: adjusted OR = 1.182, 95% CI: 1.030–1.357, P = 0.017; rs1053872 CG/GG vs CC: adjusted OR = 1.179, 95% CI: 1.040–1.337, P = 0.010). However, the remaining 9 SNPs were not significantly associated with risk of breast cancer. Additionally, combined analysis of the two high-risk SNPs revealed that subjects carrying the variant genotypes of rs462480 and rs1053872 had increased risk of breast cancer in a dose-response manner (P trend = 0.002). Compared with individuals with “0–1” risk allele, those carrying “2–4” risk alleles had 1.29-fold risk of breast cancer. In conclusion, these findings suggested that the SNPs rs462480 and rs1053872 residing in miR-101-2 gene may have a solid impact on genetic susceptibility to breast cancer, which may improve our understanding of the potential contribution of miRNA SNPs to cancer pathogenesis. Public Library of Science 2014-01-24 /pmc/articles/PMC3901682/ /pubmed/24475105 http://dx.doi.org/10.1371/journal.pone.0086319 Text en © 2014 Chen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Chen, Jiaping Qin, Zhenzhen Jiang, Yue Wang, Yanru He, Yisha Dai, Juncheng Jin, Guangfu Ma, Hongxia Hu, Zhibin Yin, Yongmei Shen, Hongbing
spellingShingle	Chen, Jiaping Qin, Zhenzhen Jiang, Yue Wang, Yanru He, Yisha Dai, Juncheng Jin, Guangfu Ma, Hongxia Hu, Zhibin Yin, Yongmei Shen, Hongbing Genetic Variations in the Flanking Regions of miR-101-2 Are Associated with Increased Risk of Breast Cancer
author_facet	Chen, Jiaping Qin, Zhenzhen Jiang, Yue Wang, Yanru He, Yisha Dai, Juncheng Jin, Guangfu Ma, Hongxia Hu, Zhibin Yin, Yongmei Shen, Hongbing
author_sort	Chen, Jiaping
title	Genetic Variations in the Flanking Regions of miR-101-2 Are Associated with Increased Risk of Breast Cancer
title_short	Genetic Variations in the Flanking Regions of miR-101-2 Are Associated with Increased Risk of Breast Cancer
title_full	Genetic Variations in the Flanking Regions of miR-101-2 Are Associated with Increased Risk of Breast Cancer
title_fullStr	Genetic Variations in the Flanking Regions of miR-101-2 Are Associated with Increased Risk of Breast Cancer
title_full_unstemmed	Genetic Variations in the Flanking Regions of miR-101-2 Are Associated with Increased Risk of Breast Cancer
title_sort	genetic variations in the flanking regions of mir-101-2 are associated with increased risk of breast cancer
description	Genetic variants in human microRNA (miRNA) genes may alter mature miRNA processing and/or target selection, and likely contribute to cancer susceptibility and disease progression. Previous studies have suggested that miR-101 may play important roles in the development of cancer by regulating key tumor-associated genes. However, the role of single nucleotide polymorphisms (SNPs) of miR-101 in breast cancer susceptibility remains unclear. In this study, we genotyped 11 SNPs of the miR-101 genes (including miR-101-1 and miR-101-2) in a case-control study of 1064 breast cancer cases and 1073 cancer-free controls. The results revealed that rs462480 and rs1053872 in the flank regions of pre-miR-101-2 were significantly associated with increased risk of breast cancer (rs462480 AC/CC vs AA: adjusted OR = 1.182, 95% CI: 1.030–1.357, P = 0.017; rs1053872 CG/GG vs CC: adjusted OR = 1.179, 95% CI: 1.040–1.337, P = 0.010). However, the remaining 9 SNPs were not significantly associated with risk of breast cancer. Additionally, combined analysis of the two high-risk SNPs revealed that subjects carrying the variant genotypes of rs462480 and rs1053872 had increased risk of breast cancer in a dose-response manner (P trend = 0.002). Compared with individuals with “0–1” risk allele, those carrying “2–4” risk alleles had 1.29-fold risk of breast cancer. In conclusion, these findings suggested that the SNPs rs462480 and rs1053872 residing in miR-101-2 gene may have a solid impact on genetic susceptibility to breast cancer, which may improve our understanding of the potential contribution of miRNA SNPs to cancer pathogenesis.
publisher	Public Library of Science
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901682/
_version_	1612051171920314368

Genetic Variations in the Flanking Regions of miR-101-2 Are Associated with Increased Risk of Breast Cancer

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