BRCA and Early Events in the Development of Serous Ovarian Cancer
Women who have an inherited mutation in the BRCA1 or BRCA2 genes have a substantial increased lifetime risk of developing epithelial ovarian cancer (EOC), and epidemiological factors related to parity, ovulation, and hormone regulation have a dramatic effect on the risk in both BRCA mutation carrier...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901362/ |
| id |
pubmed-3901362 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-39013622014-01-29 BRCA and Early Events in the Development of Serous Ovarian Cancer George, Sophia H. L. Shaw, Patricia Oncology Women who have an inherited mutation in the BRCA1 or BRCA2 genes have a substantial increased lifetime risk of developing epithelial ovarian cancer (EOC), and epidemiological factors related to parity, ovulation, and hormone regulation have a dramatic effect on the risk in both BRCA mutation carriers and non-carriers. The most common and most aggressive histotype of EOC, high-grade serous carcinoma (HGSC), is also the histotype associated with germline BRCA mutations. In recent years, evidence has emerged indicating that the likely tissue of origin of HGSC is the fallopian tube. We have reviewed, what is known about the fallopian tube in BRCA mutation carriers at both the transcriptional and translational aspect of their biology. We propose that changes of the transcriptome in BRCA heterozygotes reflect an altered response to the ovulatory stresses from the microenvironment, which may include the post-ovulation inflammatory response and altered reproductive hormone physiology. Frontiers Media S.A. 2014-01-23 /pmc/articles/PMC3901362/ /pubmed/24478985 http://dx.doi.org/10.3389/fonc.2014.00005 Text en Copyright © 2014 George and Shaw. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
George, Sophia H. L. Shaw, Patricia |
| spellingShingle |
George, Sophia H. L. Shaw, Patricia BRCA and Early Events in the Development of Serous Ovarian Cancer |
| author_facet |
George, Sophia H. L. Shaw, Patricia |
| author_sort |
George, Sophia H. L. |
| title |
BRCA and Early Events in the Development of Serous Ovarian Cancer |
| title_short |
BRCA and Early Events in the Development of Serous Ovarian Cancer |
| title_full |
BRCA and Early Events in the Development of Serous Ovarian Cancer |
| title_fullStr |
BRCA and Early Events in the Development of Serous Ovarian Cancer |
| title_full_unstemmed |
BRCA and Early Events in the Development of Serous Ovarian Cancer |
| title_sort |
brca and early events in the development of serous ovarian cancer |
| description |
Women who have an inherited mutation in the BRCA1 or BRCA2 genes have a substantial increased lifetime risk of developing epithelial ovarian cancer (EOC), and epidemiological factors related to parity, ovulation, and hormone regulation have a dramatic effect on the risk in both BRCA mutation carriers and non-carriers. The most common and most aggressive histotype of EOC, high-grade serous carcinoma (HGSC), is also the histotype associated with germline BRCA mutations. In recent years, evidence has emerged indicating that the likely tissue of origin of HGSC is the fallopian tube. We have reviewed, what is known about the fallopian tube in BRCA mutation carriers at both the transcriptional and translational aspect of their biology. We propose that changes of the transcriptome in BRCA heterozygotes reflect an altered response to the ovulatory stresses from the microenvironment, which may include the post-ovulation inflammatory response and altered reproductive hormone physiology. |
| publisher |
Frontiers Media S.A. |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901362/ |
| _version_ |
1612051065408061440 |