Recent Advances towards the Clinical Application of Stem Cells for Retinal Regeneration
Retinal degenerative diseases constitute a major cause of irreversible blindness in the world. Stem cell-based therapies offer hope for these patients at risk of or suffering from blindness due to the deterioration of the neural retina. Various sources of stem cells are currently being investigated,...
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| Format: | Online |
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MDPI
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901131/ |
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pubmed-39011312014-04-07 Recent Advances towards the Clinical Application of Stem Cells for Retinal Regeneration Becker, Silke Jayaram, Hari Limb, G. Astrid Review Retinal degenerative diseases constitute a major cause of irreversible blindness in the world. Stem cell-based therapies offer hope for these patients at risk of or suffering from blindness due to the deterioration of the neural retina. Various sources of stem cells are currently being investigated, ranging from human embryonic stem cells to adult-derived induced pluripotent stem cells as well as human Müller stem cells, with the first clinical trials to investigate the safety and tolerability of human embryonic stem cell-derived retinal pigment epithelium cells having recently commenced. This review aims to summarize the latest advances in the development of stem cell strategies for the replacement of retinal neurons and their supportive cells, the retinal pigment epithelium (RPE) affected by retinal degenerative conditions. Particular emphasis will be given to the advances in stem cell transplantation and the challenges associated with their translation into clinical practice. MDPI 2012-10-18 /pmc/articles/PMC3901131/ /pubmed/24710533 http://dx.doi.org/10.3390/cells1040851 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Becker, Silke Jayaram, Hari Limb, G. Astrid |
| spellingShingle |
Becker, Silke Jayaram, Hari Limb, G. Astrid Recent Advances towards the Clinical Application of Stem Cells for Retinal Regeneration |
| author_facet |
Becker, Silke Jayaram, Hari Limb, G. Astrid |
| author_sort |
Becker, Silke |
| title |
Recent Advances towards the Clinical Application of Stem Cells for Retinal Regeneration |
| title_short |
Recent Advances towards the Clinical Application of Stem Cells for Retinal Regeneration |
| title_full |
Recent Advances towards the Clinical Application of Stem Cells for Retinal Regeneration |
| title_fullStr |
Recent Advances towards the Clinical Application of Stem Cells for Retinal Regeneration |
| title_full_unstemmed |
Recent Advances towards the Clinical Application of Stem Cells for Retinal Regeneration |
| title_sort |
recent advances towards the clinical application of stem cells for retinal regeneration |
| description |
Retinal degenerative diseases constitute a major cause of irreversible blindness in the world. Stem cell-based therapies offer hope for these patients at risk of or suffering from blindness due to the deterioration of the neural retina. Various sources of stem cells are currently being investigated, ranging from human embryonic stem cells to adult-derived induced pluripotent stem cells as well as human Müller stem cells, with the first clinical trials to investigate the safety and tolerability of human embryonic stem cell-derived retinal pigment epithelium cells having recently commenced. This review aims to summarize the latest advances in the development of stem cell strategies for the replacement of retinal neurons and their supportive cells, the retinal pigment epithelium (RPE) affected by retinal degenerative conditions. Particular emphasis will be given to the advances in stem cell transplantation and the challenges associated with their translation into clinical practice. |
| publisher |
MDPI |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901131/ |
| _version_ |
1612050966923706368 |