MicroRNAs and Molecular Mechanisms of Neurodegeneration

During the last few years microRNAs (miRNAs) have emerged as key mediators of post-transcriptional and epigenetic regulation of gene expression. MiRNAs targets, identified through gene expression profiling and studies in animal models, depict a scenario where miRNAs are fine-tuning metabolic pathway...

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Main Authors:	Bicchi, Ilaria, Morena, Francesco, Montesano, Simona, Polidoro, Mario, Martino, Sabata
Format:	Online
Language:	English
Published:	MDPI 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899972/

id	pubmed-3899972
recordtype	oai_dc
spelling	pubmed-38999722014-03-26 MicroRNAs and Molecular Mechanisms of Neurodegeneration Bicchi, Ilaria Morena, Francesco Montesano, Simona Polidoro, Mario Martino, Sabata Review During the last few years microRNAs (miRNAs) have emerged as key mediators of post-transcriptional and epigenetic regulation of gene expression. MiRNAs targets, identified through gene expression profiling and studies in animal models, depict a scenario where miRNAs are fine-tuning metabolic pathways and genetic networks in both plants and animals. MiRNAs have shown to be differentially expressed in brain areas and alterations of miRNAs homeostasis have been recently correlated to pathological conditions of the nervous system, such as cancer and neurodegeneration. Here, we review and discuss the most recent insights into the involvement of miRNAs in the neurodegenerative mechanisms and their correlation with significant neurodegenerative disorders. MDPI 2013-05-29 /pmc/articles/PMC3899972/ /pubmed/24705162 http://dx.doi.org/10.3390/genes4020244 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Bicchi, Ilaria Morena, Francesco Montesano, Simona Polidoro, Mario Martino, Sabata
spellingShingle	Bicchi, Ilaria Morena, Francesco Montesano, Simona Polidoro, Mario Martino, Sabata MicroRNAs and Molecular Mechanisms of Neurodegeneration
author_facet	Bicchi, Ilaria Morena, Francesco Montesano, Simona Polidoro, Mario Martino, Sabata
author_sort	Bicchi, Ilaria
title	MicroRNAs and Molecular Mechanisms of Neurodegeneration
title_short	MicroRNAs and Molecular Mechanisms of Neurodegeneration
title_full	MicroRNAs and Molecular Mechanisms of Neurodegeneration
title_fullStr	MicroRNAs and Molecular Mechanisms of Neurodegeneration
title_full_unstemmed	MicroRNAs and Molecular Mechanisms of Neurodegeneration
title_sort	micrornas and molecular mechanisms of neurodegeneration
description	During the last few years microRNAs (miRNAs) have emerged as key mediators of post-transcriptional and epigenetic regulation of gene expression. MiRNAs targets, identified through gene expression profiling and studies in animal models, depict a scenario where miRNAs are fine-tuning metabolic pathways and genetic networks in both plants and animals. MiRNAs have shown to be differentially expressed in brain areas and alterations of miRNAs homeostasis have been recently correlated to pathological conditions of the nervous system, such as cancer and neurodegeneration. Here, we review and discuss the most recent insights into the involvement of miRNAs in the neurodegenerative mechanisms and their correlation with significant neurodegenerative disorders.
publisher	MDPI
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899972/
_version_	1612050543955410944

MicroRNAs and Molecular Mechanisms of Neurodegeneration

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