Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation

Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation

Microglia are crucial for the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). Here, we show that the E3 ubiquitin ligase Peli1 is abundantly expressed in microglia and serves as a pivotal mediator of microglial activation during the course of...

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Bibliographic Details
Main Authors: Xiao, Yichuan, Jin, Jin, Chang, Mikyoung, Chang, Jae-Hoon, Hu, Hongbo, Zhou, Xiaofei, Brittain, George C., Stansberg, Christine, Torkildsen, Øivind, Wang, Xiaodong, Brink, Robert, Cheng, Xuhong, Sun, Shao-Cong
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899792/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899792/

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