Nrf1 and Nrf2 Transcription Factors Regulate Androgen Receptor Transactivation in Prostate Cancer Cells

Nrf1 and Nrf2 Transcription Factors Regulate Androgen Receptor Transactivation in Prostate Cancer Cells

Despite androgen deprivation therapy (ADT), persistent androgen receptor (AR) signaling enables outgrowth of castration resistant prostate cancer (CRPC). In prostate cancer (PCa) cells, ADT may enhance AR activity through induction of oxidative stress. Herein, we investigated the roles of Nrf1 and N...

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Bibliographic Details
Main Authors: Schultz, Michelle A., Hagan, Sharika S., Datta, Amrita, Zhang, Yiguo, Freeman, Michael L., Sikka, Suresh C., Abdel-Mageed, Asim B., Mondal, Debasis
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899380/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899380/

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