Subunit Positioning and Stator Filament Stiffness in Regulation and Power Transmission in the V1 Motor of the Manduca sexta V-ATPase☆

The vacuolar H+-ATPase (V-ATPase) is an ATP-driven proton pump essential to the function of eukaryotic cells. Its cytoplasmic V1 domain is an ATPase, normally coupled to membrane-bound proton pump Vo via a rotary mechanism. How these asymmetric motors are coupled remains poorly understood. Low energ...

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Bibliographic Details
Main Authors: Muench, Stephen P., Scheres, Sjors H.W., Huss, Markus, Phillips, Clair, Vitavska, Olga, Wieczorek, Helmut, Trinick, John, Harrison, Michael A.
Format: Online
Language:English
Published: Elsevier 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899036/