Memory loss in Alzheimer's disease
Loss of memory is among the first symptoms reported by patients suffering from Alzheimer's disease (AD) and by their caretakers. Working memory and long-term declarative memory are affected early during the course of the disease. The individual pattern of impaired memory functions correlates wi...
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| Format: | Online |
| Language: | English |
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Les Laboratoires Servier
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898682/ |
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pubmed-38986822014-01-23 Memory loss in Alzheimer's disease Jahn, Holger Clinical Research Loss of memory is among the first symptoms reported by patients suffering from Alzheimer's disease (AD) and by their caretakers. Working memory and long-term declarative memory are affected early during the course of the disease. The individual pattern of impaired memory functions correlates with parameters of structural or functional brain integrity. AD pathology interferes with the formation of memories from the molecular level to the framework of neural networks. The investigation of AD memory loss helps to identify the involved neural structures, such as the default mode network, the influence of epigenetic and genetic factors, such as ApoE4 status, and evolutionary aspects of human cognition. Clinically, the analysis of memory assists the definition of AD subtypes, disease grading, and prognostic predictions. Despite new AD criteria that allow the earlier diagnosis of the disease by inclusion of biomarkers derived from cerebrospinal fluid or hippocampal volume analysis, neuropsychological testing remains at the core of AD diagnosis. Les Laboratoires Servier 2013-12 /pmc/articles/PMC3898682/ /pubmed/24459411 Text en Copyright: © 2013 Institut la Conférence Hippocrate - Servier Research Group http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Jahn, Holger |
| spellingShingle |
Jahn, Holger Memory loss in Alzheimer's disease |
| author_facet |
Jahn, Holger |
| author_sort |
Jahn, Holger |
| title |
Memory loss in Alzheimer's disease |
| title_short |
Memory loss in Alzheimer's disease |
| title_full |
Memory loss in Alzheimer's disease |
| title_fullStr |
Memory loss in Alzheimer's disease |
| title_full_unstemmed |
Memory loss in Alzheimer's disease |
| title_sort |
memory loss in alzheimer's disease |
| description |
Loss of memory is among the first symptoms reported by patients suffering from Alzheimer's disease (AD) and by their caretakers. Working memory and long-term declarative memory are affected early during the course of the disease. The individual pattern of impaired memory functions correlates with parameters of structural or functional brain integrity. AD pathology interferes with the formation of memories from the molecular level to the framework of neural networks. The investigation of AD memory loss helps to identify the involved neural structures, such as the default mode network, the influence of epigenetic and genetic factors, such as ApoE4 status, and evolutionary aspects of human cognition. Clinically, the analysis of memory assists the definition of AD subtypes, disease grading, and prognostic predictions. Despite new AD criteria that allow the earlier diagnosis of the disease by inclusion of biomarkers derived from cerebrospinal fluid or hippocampal volume analysis, neuropsychological testing remains at the core of AD diagnosis. |
| publisher |
Les Laboratoires Servier |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898682/ |
| _version_ |
1612050057563996160 |