Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response

Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response

JP2 (junctophilin-2) is believed to hold the transverse tubular and jSR (junctional sarcoplasmic reticulum) membranes in a precise geometry that facilitates excitation–contraction coupling in cardiomyocytes. We have expressed and purified human JP2 and shown using electron microscopy that the protei...

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Bibliographic Details
Main Authors: Bennett, Hayley J., Davenport, John Bernard, Collins, Richard F., Trafford, Andrew W., Pinali, Christian, Kitmitto, Ashraf
Format: Online
Language:English
Published: Portland Press Ltd. 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898329/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898329/

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