Metformin: A Potential Therapeutic Agent for Recurrent Colon Cancer

Accumulating evidence suggests that metformin, a biguanide class of anti-diabetic drugs, possesses anti-cancer properties. However, most of the studies to evaluate therapeutic efficacy of metformin have been on primary cancer. No information is available whether metformin could be effectively used f...

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Main Authors:	Nangia-Makker, Pratima, Yu, Yingjie, Vasudevan, Anita, Farhana, Lulu, Rajendra, Sindhu G., Levi, Edi, Majumdar, Adhip P. N.
Format:	Online
Language:	English
Published:	Public Library of Science 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896365/

id	pubmed-3896365
recordtype	oai_dc
spelling	pubmed-38963652014-01-24 Metformin: A Potential Therapeutic Agent for Recurrent Colon Cancer Nangia-Makker, Pratima Yu, Yingjie Vasudevan, Anita Farhana, Lulu Rajendra, Sindhu G. Levi, Edi Majumdar, Adhip P. N. Research Article Accumulating evidence suggests that metformin, a biguanide class of anti-diabetic drugs, possesses anti-cancer properties. However, most of the studies to evaluate therapeutic efficacy of metformin have been on primary cancer. No information is available whether metformin could be effectively used for recurrent cancer, specifically colorectal cancer (CRC) that affects up to 50% of patients treated by conventional chemotherapies. Although the reasons for recurrence are not fully understood, it is thought to be due to re-emergence of chemotherapy-resistant cancer stem/stem-like cells (CSCs/CSLCs). Therefore, development of non-toxic treatment strategies targeting CSCs would be of significant therapeutic benefit. Public Library of Science 2014-01-20 /pmc/articles/PMC3896365/ /pubmed/24465408 http://dx.doi.org/10.1371/journal.pone.0084369 Text en © 2014 Nangia-Makker et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Nangia-Makker, Pratima Yu, Yingjie Vasudevan, Anita Farhana, Lulu Rajendra, Sindhu G. Levi, Edi Majumdar, Adhip P. N.
spellingShingle	Nangia-Makker, Pratima Yu, Yingjie Vasudevan, Anita Farhana, Lulu Rajendra, Sindhu G. Levi, Edi Majumdar, Adhip P. N. Metformin: A Potential Therapeutic Agent for Recurrent Colon Cancer
author_facet	Nangia-Makker, Pratima Yu, Yingjie Vasudevan, Anita Farhana, Lulu Rajendra, Sindhu G. Levi, Edi Majumdar, Adhip P. N.
author_sort	Nangia-Makker, Pratima
title	Metformin: A Potential Therapeutic Agent for Recurrent Colon Cancer
title_short	Metformin: A Potential Therapeutic Agent for Recurrent Colon Cancer
title_full	Metformin: A Potential Therapeutic Agent for Recurrent Colon Cancer
title_fullStr	Metformin: A Potential Therapeutic Agent for Recurrent Colon Cancer
title_full_unstemmed	Metformin: A Potential Therapeutic Agent for Recurrent Colon Cancer
title_sort	metformin: a potential therapeutic agent for recurrent colon cancer
description	Accumulating evidence suggests that metformin, a biguanide class of anti-diabetic drugs, possesses anti-cancer properties. However, most of the studies to evaluate therapeutic efficacy of metformin have been on primary cancer. No information is available whether metformin could be effectively used for recurrent cancer, specifically colorectal cancer (CRC) that affects up to 50% of patients treated by conventional chemotherapies. Although the reasons for recurrence are not fully understood, it is thought to be due to re-emergence of chemotherapy-resistant cancer stem/stem-like cells (CSCs/CSLCs). Therefore, development of non-toxic treatment strategies targeting CSCs would be of significant therapeutic benefit.
publisher	Public Library of Science
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896365/
_version_	1612049049024724992

Metformin: A Potential Therapeutic Agent for Recurrent Colon Cancer

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