Comparative Structural and Functional Analysis of Orthomyxovirus Polymerase Cap-Snatching Domains

Comparative Structural and Functional Analysis of Orthomyxovirus Polymerase Cap-Snatching Domains

Orthomyxovirus Influenza A virus (IAV) heterotrimeric polymerase performs transcription of viral mRNAs by cap-snatching, which involves generation of capped primers by host pre-mRNA binding via the PB2 subunit cap-binding site and cleavage 10–13 nucleotides from the 5′ cap by the PA subunit endonucl...

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Bibliographic Details
Main Authors: Guilligay, Delphine, Kadlec, Jan, Crépin, Thibaut, Lunardi, Thomas, Bouvier, Denis, Kochs, Georg, Ruigrok, Rob W. H., Cusack, Stephen
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893164/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893164/

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