Bone resorption is regulated by cell-autonomous negative feedback loop of Stat5–Dusp axis in the osteoclast

The transcription factor Stat5 inhibits the bone-resorbing function of osteoclasts, in part by inducing the expression of the phosphatases Dusp1 and Dusp2.

Bibliographic Details
Main Authors: Hirose, Jun, Masuda, Hironari, Tokuyama, Naoto, Omata, Yasunori, Matsumoto, Takumi, Yasui, Tetsuro, Kadono, Yuho, Hennighausen, Lothar, Tanaka, Sakae
Format: Online
Language:English
Published: The Rockefeller University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892975/