Thermo-/pH-dual responsive properties of hyperbranched polyethylenimine grafted by phenylalanine
Novel thermo- and pH-dual responsive amphiphilic copolymers were synthesized based on hyperbranched polyethylenimine (PEI) by grafting l-phenylalanine. The phenylalanine-modified PEI exhibited lower cytotoxicity than commercial PEI. These copolymers showed the phenomena of phase transitions in respo...
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| Format: | Online |
| Language: | English |
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Springer Netherlands
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889500/ |
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pubmed-38895002014-01-14 Thermo-/pH-dual responsive properties of hyperbranched polyethylenimine grafted by phenylalanine Chen, Jie Xia, Jialiang Tian, Huayu Tang, Zhaohui He, Chaoliang Chen, Xuesi Research Article Novel thermo- and pH-dual responsive amphiphilic copolymers were synthesized based on hyperbranched polyethylenimine (PEI) by grafting l-phenylalanine. The phenylalanine-modified PEI exhibited lower cytotoxicity than commercial PEI. These copolymers showed the phenomena of phase transitions in response to pH and temperature. The dilute copolymer solution at lower pH displayed the higher LCST. Furthermore, LCST increased with the increasing of phenylalanine grafting density. LCST of these copolymers were tunable from 7.2 to 59.6 °C by the degree of amidation and pH of solution. DLS and TEM experiments certified that the copolymer chains aggregated to form small size particles as increasing the temperature above LCST. For these reasons, the obtained smart copolymers were considered to be potential gene/drug carriers in biomedical field. Springer Netherlands 2013-11-22 2014 /pmc/articles/PMC3889500/ /pubmed/24263409 http://dx.doi.org/10.1007/s12272-013-0288-y Text en © The Author(s) 2013 Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Chen, Jie Xia, Jialiang Tian, Huayu Tang, Zhaohui He, Chaoliang Chen, Xuesi |
| spellingShingle |
Chen, Jie Xia, Jialiang Tian, Huayu Tang, Zhaohui He, Chaoliang Chen, Xuesi Thermo-/pH-dual responsive properties of hyperbranched polyethylenimine grafted by phenylalanine |
| author_facet |
Chen, Jie Xia, Jialiang Tian, Huayu Tang, Zhaohui He, Chaoliang Chen, Xuesi |
| author_sort |
Chen, Jie |
| title |
Thermo-/pH-dual responsive properties of hyperbranched polyethylenimine grafted by phenylalanine |
| title_short |
Thermo-/pH-dual responsive properties of hyperbranched polyethylenimine grafted by phenylalanine |
| title_full |
Thermo-/pH-dual responsive properties of hyperbranched polyethylenimine grafted by phenylalanine |
| title_fullStr |
Thermo-/pH-dual responsive properties of hyperbranched polyethylenimine grafted by phenylalanine |
| title_full_unstemmed |
Thermo-/pH-dual responsive properties of hyperbranched polyethylenimine grafted by phenylalanine |
| title_sort |
thermo-/ph-dual responsive properties of hyperbranched polyethylenimine grafted by phenylalanine |
| description |
Novel thermo- and pH-dual responsive amphiphilic copolymers were synthesized based on hyperbranched polyethylenimine (PEI) by grafting l-phenylalanine. The phenylalanine-modified PEI exhibited lower cytotoxicity than commercial PEI. These copolymers showed the phenomena of phase transitions in response to pH and temperature. The dilute copolymer solution at lower pH displayed the higher LCST. Furthermore, LCST increased with the increasing of phenylalanine grafting density. LCST of these copolymers were tunable from 7.2 to 59.6 °C by the degree of amidation and pH of solution. DLS and TEM experiments certified that the copolymer chains aggregated to form small size particles as increasing the temperature above LCST. For these reasons, the obtained smart copolymers were considered to be potential gene/drug carriers in biomedical field. |
| publisher |
Springer Netherlands |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889500/ |
| _version_ |
1612046827397316608 |