BH3-Only Protein BIM Mediates Heat Shock-Induced Apoptosis

BH3-Only Protein BIM Mediates Heat Shock-Induced Apoptosis

Acute heat shock can induce apoptosis through a canonical pathway involving the upstream activation of caspase-2, followed by BID cleavage and stimulation of the intrinsic pathway. Herein, we report that the BH3-only protein BIM, rather than BID, is essential to heat shock-induced cell death. We obs...

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Bibliographic Details
Main Authors: Mahajan, Indra M., Chen, Miao-Der, Muro, Israel, Robertson, John D., Wright, Casey W., Bratton, Shawn B.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888412/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888412/

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