Longterm-habituation of the startle response in mice is stimulus modality, but not context specific

In mice, the specificity of longterm-habituation (LTH) of startle was tested in two experiments. In two strains of mice (C57Bl/6 and C3H) there was pronounced LTH over 10 days of acoustic stimulation in two different contexts of startle measurement. (We found LTH to be greater after stimulation with...

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Main Authors:	Pilz, Peter K. D., Arnold, Stephan W., Rischawy, Anja T., Plappert, Claudia F.
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885814/

id	pubmed-3885814
recordtype	oai_dc
spelling	pubmed-38858142014-01-09 Longterm-habituation of the startle response in mice is stimulus modality, but not context specific Pilz, Peter K. D. Arnold, Stephan W. Rischawy, Anja T. Plappert, Claudia F. Neuroscience In mice, the specificity of longterm-habituation (LTH) of startle was tested in two experiments. In two strains of mice (C57Bl/6 and C3H) there was pronounced LTH over 10 days of acoustic stimulation in two different contexts of startle measurement. (We found LTH to be greater after stimulation with 14 kHz sine stimuli compared to noise or tactile stimuli). A change of context showed LTH to be independent of context, i.e., startle LTH in mice is a non-associative learning process. In the second experiment, 9 days of acoustic or tactile stimulation were given to C57B/6 mice. Both stimulus modalities produced LTH. When on the 10th day stimuli of the other modality were given, in both cases the long term habituated group showed no lower startle amplitude than a non-stimulated control group. This indicates LTH is stimulus-modality specific. Altogether, our results show that in mice—very similar to rats—LTH of startle is stimulus modality, but not context specific. In addition we found two indications that the LTH action site is on the sensory branch of the startle circuit. Frontiers Media S.A. 2014-01-09 /pmc/articles/PMC3885814/ /pubmed/24409126 http://dx.doi.org/10.3389/fnint.2013.00103 Text en Copyright © 2014 Pilz, Arnold, Rischawy and Plappert. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Pilz, Peter K. D. Arnold, Stephan W. Rischawy, Anja T. Plappert, Claudia F.
spellingShingle	Pilz, Peter K. D. Arnold, Stephan W. Rischawy, Anja T. Plappert, Claudia F. Longterm-habituation of the startle response in mice is stimulus modality, but not context specific
author_facet	Pilz, Peter K. D. Arnold, Stephan W. Rischawy, Anja T. Plappert, Claudia F.
author_sort	Pilz, Peter K. D.
title	Longterm-habituation of the startle response in mice is stimulus modality, but not context specific
title_short	Longterm-habituation of the startle response in mice is stimulus modality, but not context specific
title_full	Longterm-habituation of the startle response in mice is stimulus modality, but not context specific
title_fullStr	Longterm-habituation of the startle response in mice is stimulus modality, but not context specific
title_full_unstemmed	Longterm-habituation of the startle response in mice is stimulus modality, but not context specific
title_sort	longterm-habituation of the startle response in mice is stimulus modality, but not context specific
description	In mice, the specificity of longterm-habituation (LTH) of startle was tested in two experiments. In two strains of mice (C57Bl/6 and C3H) there was pronounced LTH over 10 days of acoustic stimulation in two different contexts of startle measurement. (We found LTH to be greater after stimulation with 14 kHz sine stimuli compared to noise or tactile stimuli). A change of context showed LTH to be independent of context, i.e., startle LTH in mice is a non-associative learning process. In the second experiment, 9 days of acoustic or tactile stimulation were given to C57B/6 mice. Both stimulus modalities produced LTH. When on the 10th day stimuli of the other modality were given, in both cases the long term habituated group showed no lower startle amplitude than a non-stimulated control group. This indicates LTH is stimulus-modality specific. Altogether, our results show that in mice—very similar to rats—LTH of startle is stimulus modality, but not context specific. In addition we found two indications that the LTH action site is on the sensory branch of the startle circuit.
publisher	Frontiers Media S.A.
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885814/
_version_	1612045915603861504

Longterm-habituation of the startle response in mice is stimulus modality, but not context specific

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