Roflumilast N-Oxide Prevents Cytokine Secretion Induced by Cigarette Smoke Combined with LPS through JAK/STAT and ERK1/2 Inhibition in Airway Epithelial Cells

Roflumilast N-Oxide Prevents Cytokine Secretion Induced by Cigarette Smoke Combined with LPS through JAK/STAT and ERK1/2 Inhibition in Airway Epithelial Cells

Cigarette smoke is a major cause of chronic obstructive pulmonary disease (COPD). Airway epithelial cells and macrophages are the first defense cells against cigarette smoke and these cells are an important source of pro-inflammatory cytokines. These cytokines play a role in progressive airflow limi...

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Bibliographic Details
Main Authors: Victoni, Tatiana, Gleonnec, Florence, Lanzetti, Manuella, Tenor, Hermann, Valença, Samuel, Porto, Luis Cristovão, Lagente, Vincent, Boichot, Elisabeth
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885699/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885699/

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