Improving aqueous solubility and antitumor effects by nanosized gambogic acid-mPEG2000 micelles
The clinical application of gambogic acid, a natural component with promising antitumor activity, is limited due to its extremely poor aqueous solubility, short half-life in blood, and severe systemic toxicity. To solve these problems, an amphiphilic polymer-drug conjugate was prepared by attachment...
| Main Authors: | , , , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Dove Medical Press
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883552/ |