Biphenotypic Acute Leukemia with t(15;17) Lacking Promyelocytic-retinoid Acid Receptor α Rearrangement

Biphenotypic acute leukemias (BAL) account for less than 4% of all cases of acute leukemia. Philadelphia chromosome and 11q23 rearrangement are the most frequently found cytogenetic abnormalities. Since t(15;17) is almost always associated with acute promyelocytic leukemia, t(15;17) in BAL cases is...

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Main Authors:	Saito, Makoto, Izumiyama, Koh, Mori, Akio, Irie, Tatsuro, Tanaka, Masanori, Morioka, Masanobu, Musashi, Manabu
Format:	Online
Language:	English
Published:	PAGEPress Publications, Pavia, Italy 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883063/

id	pubmed-3883063
recordtype	oai_dc
spelling	pubmed-38830632014-01-10 Biphenotypic Acute Leukemia with t(15;17) Lacking Promyelocytic-retinoid Acid Receptor α Rearrangement Saito, Makoto Izumiyama, Koh Mori, Akio Irie, Tatsuro Tanaka, Masanori Morioka, Masanobu Musashi, Manabu Case Report Biphenotypic acute leukemias (BAL) account for less than 4% of all cases of acute leukemia. Philadelphia chromosome and 11q23 rearrangement are the most frequently found cytogenetic abnormalities. Since t(15;17) is almost always associated with acute promyelocytic leukemia, t(15;17) in BAL cases is extremely uncommon. We report here a rare and instructive case of BAL with t(15;17) and the successful treatment approach adopted. A 55-year old woman was referred to our hospital for an examination of elevated white blood cell (WBC) counts with blasts (WBC 13.4×109/L; 76% blasts). The blasts with acute lymphoblastic leukemia (ALL-L2, FAB) morphology co-expressed B-lymphoid and myeloid lineages, and a cytogenetic study revealed 4q21 abnormalities and t(15;17). However, promyelocytic-retinoid acid receptor α rearrangement was not detected by fluorescence in situ hybridization on interphase nuclei. Our patient was treated with chemotherapy for ALL and gemtuzumab ozogamicin without all-trans-retinoic acid, and has remained in hematologic first complete remission for more than 3.7 years. PAGEPress Publications, Pavia, Italy 2013-12-04 /pmc/articles/PMC3883063/ /pubmed/24416501 http://dx.doi.org/10.4081/hr.2013.e16 Text en ©Copyright M. Saito et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Saito, Makoto Izumiyama, Koh Mori, Akio Irie, Tatsuro Tanaka, Masanori Morioka, Masanobu Musashi, Manabu
spellingShingle	Saito, Makoto Izumiyama, Koh Mori, Akio Irie, Tatsuro Tanaka, Masanori Morioka, Masanobu Musashi, Manabu Biphenotypic Acute Leukemia with t(15;17) Lacking Promyelocytic-retinoid Acid Receptor α Rearrangement
author_facet	Saito, Makoto Izumiyama, Koh Mori, Akio Irie, Tatsuro Tanaka, Masanori Morioka, Masanobu Musashi, Manabu
author_sort	Saito, Makoto
title	Biphenotypic Acute Leukemia with t(15;17) Lacking Promyelocytic-retinoid Acid Receptor α Rearrangement
title_short	Biphenotypic Acute Leukemia with t(15;17) Lacking Promyelocytic-retinoid Acid Receptor α Rearrangement
title_full	Biphenotypic Acute Leukemia with t(15;17) Lacking Promyelocytic-retinoid Acid Receptor α Rearrangement
title_fullStr	Biphenotypic Acute Leukemia with t(15;17) Lacking Promyelocytic-retinoid Acid Receptor α Rearrangement
title_full_unstemmed	Biphenotypic Acute Leukemia with t(15;17) Lacking Promyelocytic-retinoid Acid Receptor α Rearrangement
title_sort	biphenotypic acute leukemia with t(15;17) lacking promyelocytic-retinoid acid receptor α rearrangement
description	Biphenotypic acute leukemias (BAL) account for less than 4% of all cases of acute leukemia. Philadelphia chromosome and 11q23 rearrangement are the most frequently found cytogenetic abnormalities. Since t(15;17) is almost always associated with acute promyelocytic leukemia, t(15;17) in BAL cases is extremely uncommon. We report here a rare and instructive case of BAL with t(15;17) and the successful treatment approach adopted. A 55-year old woman was referred to our hospital for an examination of elevated white blood cell (WBC) counts with blasts (WBC 13.4×109/L; 76% blasts). The blasts with acute lymphoblastic leukemia (ALL-L2, FAB) morphology co-expressed B-lymphoid and myeloid lineages, and a cytogenetic study revealed 4q21 abnormalities and t(15;17). However, promyelocytic-retinoid acid receptor α rearrangement was not detected by fluorescence in situ hybridization on interphase nuclei. Our patient was treated with chemotherapy for ALL and gemtuzumab ozogamicin without all-trans-retinoic acid, and has remained in hematologic first complete remission for more than 3.7 years.
publisher	PAGEPress Publications, Pavia, Italy
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883063/
_version_	1612044910011088896

Biphenotypic Acute Leukemia with t(15;17) Lacking Promyelocytic-retinoid Acid Receptor α Rearrangement

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