Caenorhabditis elegans as a model system for studying non-cell-autonomous mechanisms in protein-misfolding diseases

Caenorhabditis elegans has a number of distinct advantages that are useful for understanding the basis for cellular and organismal dysfunction underlying age-associated diseases of protein misfolding. Although protein aggregation, a key feature of human neurodegenerative diseases, has been typically...

Full description

Bibliographic Details
Main Authors: Nussbaum-Krammer, Carmen I., Morimoto, Richard I.
Format: Online
Language:English
Published: The Company of Biologists Limited 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882046/