Analysis of the Vaccine Potential of Plasmid DNA Encoding Nine Mycolactone Polyketide Synthase Domains in Mycobacterium ulcerans Infected Mice

Analysis of the Vaccine Potential of Plasmid DNA Encoding Nine Mycolactone Polyketide Synthase Domains in Mycobacterium ulcerans Infected Mice

There is no effective vaccine against Buruli ulcer. In experimental footpad infection of C57BL/6 mice with M. ulcerans, a prime-boost vaccination protocol using plasmid DNA encoding mycolyltransferase Ag85A of M. ulcerans and a homologous protein boost has shown significant, albeit transient protect...

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Bibliographic Details
Main Authors: Roupie, Virginie, Pidot, Sacha J., Einarsdottir, Tobba, Van Den Poel, Christophe, Jurion, Fabienne, Stinear, Timothy P., Huygen, Kris
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879250/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879250/

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