Prenatal and Postnatal Polycyclic Aromatic Hydrocarbon Exposure, Airway Hyperreactivity, and Beta-2 Adrenergic Receptor Function in Sensitized Mouse Offspring

Prenatal and Postnatal Polycyclic Aromatic Hydrocarbon Exposure, Airway Hyperreactivity, and Beta-2 Adrenergic Receptor Function in Sensitized Mouse Offspring

Despite data associating exposure to traffic-related polycyclic aromatic hydrocarbons (PAH) in asthma, mechanistic support has been limited. We hypothesized that both prenatal and early postnatal exposure to PAH would increase airway hyperreactivity (AHR) and that the resulting AHR may be insensitiv...

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Bibliographic Details
Main Authors: Chu, Sophie, Zhang, Hanjie, Maher, Christina, McDonald, Jacob D., Zhang, Xiang, Ho, Shuk-Mei, Yan, Beizhan, Chillrud, Steven, Perera, Frederica, Factor, Phillip, Miller, Rachel L.
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876588/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876588/

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