Towards the Biological Understanding of CTC: Capture Technologies, Definitions and Potential to Create Metastasis

Circulating Tumor Cells (CTC) are rare cells originated from tumors that travel into the blood stream, extravasate to different organs of which only a small fraction will develop into metastasis. The presence of CTC enumerated with the CellSearch system is associated with a relative short survival a...

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Main Authors:	Barradas, Ana M.C., Terstappen, Leon W.M.M.
Format:	Online
Language:	English
Published:	MDPI 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875957/

id	pubmed-3875957
recordtype	oai_dc
spelling	pubmed-38759572013-12-31 Towards the Biological Understanding of CTC: Capture Technologies, Definitions and Potential to Create Metastasis Barradas, Ana M.C. Terstappen, Leon W.M.M. Review Circulating Tumor Cells (CTC) are rare cells originated from tumors that travel into the blood stream, extravasate to different organs of which only a small fraction will develop into metastasis. The presence of CTC enumerated with the CellSearch system is associated with a relative short survival and their continued presence after the first cycles of therapy indicates a futile therapy in patients with metastatic carcinomas. Detailed characterization of CTC holds the promise to enable the choice of the optimal therapy for the individual patients during the course of the disease. The phenotype, physical and biological properties are however not well understood making it difficult to assess the merit of recent technological advancements to improve upon the capture of CTC or to evaluate their metastatic potential. Here we will discuss the recent advances in the classification of CTC captured by the CellSearch system, the implications of their features and numbers. Latest capture platforms are reviewed and placed in the light of technology improvements needed to detect CTC. Physical properties, phenotype, viability and proliferative potential and means to assess their proliferation and metastatic capacity will be summarized and placed in the context of the latest CTC capture platforms. MDPI 2013-12-04 /pmc/articles/PMC3875957/ /pubmed/24305653 http://dx.doi.org/10.3390/cancers5041619 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Barradas, Ana M.C. Terstappen, Leon W.M.M.
spellingShingle	Barradas, Ana M.C. Terstappen, Leon W.M.M. Towards the Biological Understanding of CTC: Capture Technologies, Definitions and Potential to Create Metastasis
author_facet	Barradas, Ana M.C. Terstappen, Leon W.M.M.
author_sort	Barradas, Ana M.C.
title	Towards the Biological Understanding of CTC: Capture Technologies, Definitions and Potential to Create Metastasis
title_short	Towards the Biological Understanding of CTC: Capture Technologies, Definitions and Potential to Create Metastasis
title_full	Towards the Biological Understanding of CTC: Capture Technologies, Definitions and Potential to Create Metastasis
title_fullStr	Towards the Biological Understanding of CTC: Capture Technologies, Definitions and Potential to Create Metastasis
title_full_unstemmed	Towards the Biological Understanding of CTC: Capture Technologies, Definitions and Potential to Create Metastasis
title_sort	towards the biological understanding of ctc: capture technologies, definitions and potential to create metastasis
description	Circulating Tumor Cells (CTC) are rare cells originated from tumors that travel into the blood stream, extravasate to different organs of which only a small fraction will develop into metastasis. The presence of CTC enumerated with the CellSearch system is associated with a relative short survival and their continued presence after the first cycles of therapy indicates a futile therapy in patients with metastatic carcinomas. Detailed characterization of CTC holds the promise to enable the choice of the optimal therapy for the individual patients during the course of the disease. The phenotype, physical and biological properties are however not well understood making it difficult to assess the merit of recent technological advancements to improve upon the capture of CTC or to evaluate their metastatic potential. Here we will discuss the recent advances in the classification of CTC captured by the CellSearch system, the implications of their features and numbers. Latest capture platforms are reviewed and placed in the light of technology improvements needed to detect CTC. Physical properties, phenotype, viability and proliferative potential and means to assess their proliferation and metastatic capacity will be summarized and placed in the context of the latest CTC capture platforms.
publisher	MDPI
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875957/
_version_	1612042516805189632

Towards the Biological Understanding of CTC: Capture Technologies, Definitions and Potential to Create Metastasis

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