Ascorbic acid insufficiency induces the severe defect on bone formation via the down-regulation of osteocalcin production

Ascorbic acid insufficiency induces the severe defect on bone formation via the down-regulation of osteocalcin production

The L-gulono-γ-lactone oxidase gene (Gulo) encodes an essential enzyme in the synthesis of ascorbic acid from glucose. On the basis of previous findings of bone abnormalities in Gulo-/- mice under conditions of ascorbic acid insufficiency, we investigated the effect of ascorbic acid insufficiency on...

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Bibliographic Details
Main Authors: Kim, Won, Bae, Seyeon, Kim, Hyemin, Kim, Yejin, Choi, Jiwon, Lim, Sun Young, Lee, Hei Jin, Lee, Jihyuk, Choi, Jiyea, Jang, Mirim, Lee, Kyoung Eun, Chung, Sun G., Hwang, Young-il, Kang, Jae Seung, Lee, Wang Jae
Format: Online
Language:English
Published: Korean Association of Anatomists 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875843/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875843/

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