Co-expression of t(15;17) and t(8;21) in a Case of Acute Promyelocytic Leukemia: Review of the Literature

Additional chromosomal abnormalities in acute myelogenous leukemia have been identified as one of the most important prognostic factors. Favorable chromosomal changes such as t(8;21), inv(16), and t(15;17) are associated with higher rates of complete remission and event-free survival. Translocation...

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Main Authors: UZ, Burak, Eliaçık, Eylem, Işık, Ayse, Aksu, Salih, Büyükaşık, Yahya, Haznedaroğlu, İbrahim C., Göker, Hakan, Sayınalp, Nilgün, Özcebe, Osman İ.
Format: Online
Language:English
Published: Galenos Publishing 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874972/
id pubmed-3874972
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spelling pubmed-38749722014-01-02 Co-expression of t(15;17) and t(8;21) in a Case of Acute Promyelocytic Leukemia: Review of the Literature UZ, Burak Eliaçık, Eylem Işık, Ayse Aksu, Salih Büyükaşık, Yahya Haznedaroğlu, İbrahim C. Göker, Hakan Sayınalp, Nilgün Özcebe, Osman İ. Case Report Additional chromosomal abnormalities in acute myelogenous leukemia have been identified as one of the most important prognostic factors. Favorable chromosomal changes such as t(8;21), inv(16), and t(15;17) are associated with higher rates of complete remission and event-free survival. Translocation (15;17) characterizes acute promyelocytic leukemia (APL) (French-American-British class M3) in almost all patients. Secondary chromosomal abnormalities are also present in approximately 23%-29% of patients with newly diagnosed APL. The prognostic implications of t(8;21) and other secondary cytogenetic aberrations in APL are reviewed here. We present a 47-year-old woman diagnosed with APL whose initial cytogenetic analysis included both t(8;21) and t(15;17). The initial induction chemotherapy included 3 days of idarubicin (12 mg/m2/day) and daily all-trans retinoic acid (ATRA; 45 mg/m2/day). At the sixth week of treatment, a control bone marrow biopsy was found to be normocellular, t(15;17) bcr3 and t(8;21) were negative, and t(15;17) bcr1 fusion transcripts were reduced from 5007 (1.78525699%) copies per 1 µg RNA to 40 (0.00062020%) with real-time quantitative polymerase chain reaction. Consolidation with 4 days of idarubicin (5 mg/m2/day), ATRA (45 mg/m2/day for 15 days), and cytarabine (1 g/m2/day for 4 days) was then started. However, the patient became pancytopenic and had neutropenic fever after consolidation treatment. Unfortunately, she died 3 months after the time of APL diagnosis, due to acute respiratory distress syndrome-like respiratory problems and multiorgan dysfunction requiring respiratory support and hemodialysis. Galenos Publishing 2013-12 2013-12-05 /pmc/articles/PMC3874972/ /pubmed/24385831 http://dx.doi.org/10.4274/Tjh.2012.0180 Text en © Turkish Journal of Hematology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author UZ, Burak
Eliaçık, Eylem
Işık, Ayse
Aksu, Salih
Büyükaşık, Yahya
Haznedaroğlu, İbrahim C.
Göker, Hakan
Sayınalp, Nilgün
Özcebe, Osman İ.
spellingShingle UZ, Burak
Eliaçık, Eylem
Işık, Ayse
Aksu, Salih
Büyükaşık, Yahya
Haznedaroğlu, İbrahim C.
Göker, Hakan
Sayınalp, Nilgün
Özcebe, Osman İ.
Co-expression of t(15;17) and t(8;21) in a Case of Acute Promyelocytic Leukemia: Review of the Literature
author_facet UZ, Burak
Eliaçık, Eylem
Işık, Ayse
Aksu, Salih
Büyükaşık, Yahya
Haznedaroğlu, İbrahim C.
Göker, Hakan
Sayınalp, Nilgün
Özcebe, Osman İ.
author_sort UZ, Burak
title Co-expression of t(15;17) and t(8;21) in a Case of Acute Promyelocytic Leukemia: Review of the Literature
title_short Co-expression of t(15;17) and t(8;21) in a Case of Acute Promyelocytic Leukemia: Review of the Literature
title_full Co-expression of t(15;17) and t(8;21) in a Case of Acute Promyelocytic Leukemia: Review of the Literature
title_fullStr Co-expression of t(15;17) and t(8;21) in a Case of Acute Promyelocytic Leukemia: Review of the Literature
title_full_unstemmed Co-expression of t(15;17) and t(8;21) in a Case of Acute Promyelocytic Leukemia: Review of the Literature
title_sort co-expression of t(15;17) and t(8;21) in a case of acute promyelocytic leukemia: review of the literature
description Additional chromosomal abnormalities in acute myelogenous leukemia have been identified as one of the most important prognostic factors. Favorable chromosomal changes such as t(8;21), inv(16), and t(15;17) are associated with higher rates of complete remission and event-free survival. Translocation (15;17) characterizes acute promyelocytic leukemia (APL) (French-American-British class M3) in almost all patients. Secondary chromosomal abnormalities are also present in approximately 23%-29% of patients with newly diagnosed APL. The prognostic implications of t(8;21) and other secondary cytogenetic aberrations in APL are reviewed here. We present a 47-year-old woman diagnosed with APL whose initial cytogenetic analysis included both t(8;21) and t(15;17). The initial induction chemotherapy included 3 days of idarubicin (12 mg/m2/day) and daily all-trans retinoic acid (ATRA; 45 mg/m2/day). At the sixth week of treatment, a control bone marrow biopsy was found to be normocellular, t(15;17) bcr3 and t(8;21) were negative, and t(15;17) bcr1 fusion transcripts were reduced from 5007 (1.78525699%) copies per 1 µg RNA to 40 (0.00062020%) with real-time quantitative polymerase chain reaction. Consolidation with 4 days of idarubicin (5 mg/m2/day), ATRA (45 mg/m2/day for 15 days), and cytarabine (1 g/m2/day for 4 days) was then started. However, the patient became pancytopenic and had neutropenic fever after consolidation treatment. Unfortunately, she died 3 months after the time of APL diagnosis, due to acute respiratory distress syndrome-like respiratory problems and multiorgan dysfunction requiring respiratory support and hemodialysis.
publisher Galenos Publishing
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874972/
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