Mek inhibition results in marked antitumor activity against metastatic melanoma patient-derived melanospheres and in melanosphere-generated xenografts

Mek inhibition results in marked antitumor activity against metastatic melanoma patient-derived melanospheres and in melanosphere-generated xenografts

One of the key oncogenic pathways involved in melanoma aggressiveness, development and progression is the RAS/BRAF/MEK pathway, whose alterations are found in most patients. These molecular anomalies are promising targets for more effective anti-cancer therapies. Some Mek inhibitors showed promising...

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Bibliographic Details
Main Authors: Sette, Giovanni, Fecchi, Katia, Salvati, Valentina, Lotti, Fiorenza, Pilozzi, Emanuela, Duranti, Enrico, Biffoni, Mauro, Pagliuca, Alfredo, Martinetti, Daniela, Memeo, Lorenzo, Milella, Michele, De Maria, Ruggero, Eramo, Adriana
Format: Online
Language:English
Published: BioMed Central 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874650/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874650/

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