Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity

Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity

LINE-1 (L1) retrotransposons are mobile genetic elements whose extensive proliferation resulted in the generation of ∼34% of the human genome. They have been shown to be a cause of single-gene diseases. Moreover, L1-encoded endonuclease can elicit double-strand breaks that may lead to genomic instab...

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Bibliographic Details
Main Authors: Horn, Axel V., Klawitter, Sabine, Held, Ulrike, Berger, André, Jaguva Vasudevan, Ananda Ayyappan, Bock, Anja, Hofmann, Henning, Hanschmann, Kay-Martin O., Trösemeier, Jan-Hendrik, Flory, Egbert, Jabulowsky, Robert A., Han, Jeffrey S., Löwer, Johannes, Löwer, Roswitha, Münk, Carsten, Schumann, Gerald G.
Format: Online
Language:English
Published: Oxford University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874205/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874205/

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